Pseudotime dynamics of T cells in pancreatic ductal adenocarcinoma inform distinct functional states within the regulatory and cytotoxic T cells

Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest types of cancer and has a 5-year survival of less than 8% owing to its complex biology. As PDAC is refractory to immunotherapy, we need to understand the functional dynamics of T cells in the PDAC microenvironment to develop alternative...

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Detalles Bibliográficos
Autores principales: Jainarayanan, Ashwin, Mouroug-Anand, Nithishwer, Arbe-Barnes, Edward H., Bush, Adam J., Bashford-Rogers, Rachael, Frampton, Adam, Heij, Lara, Middleton, Mark, Dustin, Michael L., Abu-Shah, Enas, Sivakumar, Shivan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10034436/
https://www.ncbi.nlm.nih.gov/pubmed/36968070
http://dx.doi.org/10.1016/j.isci.2023.106324

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