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High Homocysteine Levels During Pregnancy and Its Association With Placenta-Mediated Complications: A Scoping Review

There is already abundant corroboration indicating that elevated serum homocysteine levels may be related to the risk of coronary, cerebral, and peripheral arterial diseases. High homocysteine levels have often been associated with placental vasculopathies and complications related to the placenta,...

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Autores principales: Thakur, Priyanka, Bhalerao, Anuja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10034471/
https://www.ncbi.nlm.nih.gov/pubmed/36968916
http://dx.doi.org/10.7759/cureus.35244
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author Thakur, Priyanka
Bhalerao, Anuja
author_facet Thakur, Priyanka
Bhalerao, Anuja
author_sort Thakur, Priyanka
collection PubMed
description There is already abundant corroboration indicating that elevated serum homocysteine levels may be related to the risk of coronary, cerebral, and peripheral arterial diseases. High homocysteine levels have often been associated with placental vasculopathies and complications related to the placenta, such as fetal growth restriction, Abruption, hypertensive disorders of pregnancy, and recurrent abortions. This scoping review aims to integrate the currently available scientific literature and fill the gaps in our understanding of homocysteine metabolism during pregnancy and its relationship to placenta-mediated complications. Moreover, to summarize the existing literature on the correlation between raised maternal homocysteine levels in early gestation and its association with placenta-mediated complications. We developed this scoping review article by performing a literature review as per the Preferred Reporting Items for Systematic reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR) guidelines and the search was conducted using PRISMA-S (an extension to PRISMA focusing on reporting the search components of systematic reviews) guidelines. The research question was clarified and modified using keywords with important literature published online between 2010 and 2022, which were included from PubMed, and Google Scholar databases with recognized titles and abstracts were examined and cross-checked for case overlap to choose the original reports. A summary of the descriptive data was organized according to the clinical manifestations (symptoms, imaging, and laboratory results) and outcomes (maternal and perinatal). In conclusion, a review of research papers from 2010 to 2022 showed that homocysteine levels during pregnancy fluctuate and are probably influenced by a population's regional, cultural, and socioeconomic status. According to the data, there is an association between elevated homocysteine levels and complications of pregnancies, such as early spontaneous abortions, pre-eclampsia, fetal development restriction, and abruption, as well as in certain cases of maternal and fetal mortality.
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spelling pubmed-100344712023-03-24 High Homocysteine Levels During Pregnancy and Its Association With Placenta-Mediated Complications: A Scoping Review Thakur, Priyanka Bhalerao, Anuja Cureus Obstetrics/Gynecology There is already abundant corroboration indicating that elevated serum homocysteine levels may be related to the risk of coronary, cerebral, and peripheral arterial diseases. High homocysteine levels have often been associated with placental vasculopathies and complications related to the placenta, such as fetal growth restriction, Abruption, hypertensive disorders of pregnancy, and recurrent abortions. This scoping review aims to integrate the currently available scientific literature and fill the gaps in our understanding of homocysteine metabolism during pregnancy and its relationship to placenta-mediated complications. Moreover, to summarize the existing literature on the correlation between raised maternal homocysteine levels in early gestation and its association with placenta-mediated complications. We developed this scoping review article by performing a literature review as per the Preferred Reporting Items for Systematic reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR) guidelines and the search was conducted using PRISMA-S (an extension to PRISMA focusing on reporting the search components of systematic reviews) guidelines. The research question was clarified and modified using keywords with important literature published online between 2010 and 2022, which were included from PubMed, and Google Scholar databases with recognized titles and abstracts were examined and cross-checked for case overlap to choose the original reports. A summary of the descriptive data was organized according to the clinical manifestations (symptoms, imaging, and laboratory results) and outcomes (maternal and perinatal). In conclusion, a review of research papers from 2010 to 2022 showed that homocysteine levels during pregnancy fluctuate and are probably influenced by a population's regional, cultural, and socioeconomic status. According to the data, there is an association between elevated homocysteine levels and complications of pregnancies, such as early spontaneous abortions, pre-eclampsia, fetal development restriction, and abruption, as well as in certain cases of maternal and fetal mortality. Cureus 2023-02-20 /pmc/articles/PMC10034471/ /pubmed/36968916 http://dx.doi.org/10.7759/cureus.35244 Text en Copyright © 2023, Thakur et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Obstetrics/Gynecology
Thakur, Priyanka
Bhalerao, Anuja
High Homocysteine Levels During Pregnancy and Its Association With Placenta-Mediated Complications: A Scoping Review
title High Homocysteine Levels During Pregnancy and Its Association With Placenta-Mediated Complications: A Scoping Review
title_full High Homocysteine Levels During Pregnancy and Its Association With Placenta-Mediated Complications: A Scoping Review
title_fullStr High Homocysteine Levels During Pregnancy and Its Association With Placenta-Mediated Complications: A Scoping Review
title_full_unstemmed High Homocysteine Levels During Pregnancy and Its Association With Placenta-Mediated Complications: A Scoping Review
title_short High Homocysteine Levels During Pregnancy and Its Association With Placenta-Mediated Complications: A Scoping Review
title_sort high homocysteine levels during pregnancy and its association with placenta-mediated complications: a scoping review
topic Obstetrics/Gynecology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10034471/
https://www.ncbi.nlm.nih.gov/pubmed/36968916
http://dx.doi.org/10.7759/cureus.35244
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