Luseogliflozin and caloric intake restriction increase superoxide dismutase 2 expression, promote antioxidative effects, and attenuate aortic endothelial dysfunction in diet‐induced obese mice

AIMS/INTRODUCTION: The mechanisms underlying the effect of sodium‐glucose cotransporter 2 (SGLT2) inhibitors on aortic endothelial dysfunction in diet‐induced obesity are not clearly understood. This study investigated whether SGLT2 inhibition by luseogliflozin improved free fatty acid (FFA)‐induced...

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Autores principales: Kawade, Shigeru, Ogiso, Kazuma, Shayo, Sigfrid Casmir, Obo, Takahiko, Arimura, Aiko, Hashiguchi, Hiroshi, Deguchi, Takahisa, Nishio, Yoshihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10034951/
https://www.ncbi.nlm.nih.gov/pubmed/36729938
http://dx.doi.org/10.1111/jdi.13981

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