Cargando…
Therapeutic drug monitoring guided dosing versus standard dosing of alectinib in advanced ALK positive non-small cell lung cancer patients: Study protocol for an international, multicenter phase IV randomized controlled trial (ADAPT ALEC)
BACKGROUND: Alectinib is first-line therapy in patients with stage IV non-small cell lung carcinoma (NSCLC) and an anaplastic lymphoma kinase (ALK) fusion. A shorter median progression-free survival (mPFS) was observed when alectinib minimum plasma concentrations during steady state (C(min,SS)) were...
Autores principales: | Meertens, Marinda, Muntinghe-Wagenaar, M. Benthe, Sikkema, Barend J., Lopez-Yurda, Marta, Retèl, Valesca P., Paats, Marthe S., Ter Heine, Rob, Schuuring, Ed, Timens, Wim, Touw, Daan J., van Boven, Job F. M., de Langen, Adrianus. J., Hashemi, Sayed M. S., Hendriks, Lizza E. L., Croes, Sander, van den Heuvel, Michel M., Dingemans, Anne-Marie C., Mathijssen, Ron H. J., Smit, Egbert F., Huitema, Alwin D. R., Steeghs, Neeltje, van der Wekken, Anthonie J. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10035072/ https://www.ncbi.nlm.nih.gov/pubmed/36969063 http://dx.doi.org/10.3389/fonc.2023.1136221 |
Ejemplares similares
-
Sir Alec Merrison
Publicado: (1989) -
Obituary: Alec Coppen
por: Bunney, William E
Publicado: (2019) -
Captain Alec Robb-Smith
Publicado: (1918) -
First person – Alec Nickolls
Publicado: (2020) -
Mutations in EMT-Related Genes in ALK Positive Crizotinib Resistant Non-Small Cell Lung Cancers
por: Wei, Jiacong, et al.
Publicado: (2018)