Cargando…
A retrospective analysis of conditional power assumptions in clinical trials with continuous or binary endpoints
BACKGROUND: Adaptive clinical trials may use conditional power (CP) to make decisions at interim analyses, requiring assumptions about the treatment effect for remaining patients. It is critical that these assumptions are understood by those using CP in decision-making, as well as timings of these d...
Autores principales: | Edwards, Julia M., Walters, Stephen J., Julious, Steven A. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10035140/ https://www.ncbi.nlm.nih.gov/pubmed/36949524 http://dx.doi.org/10.1186/s13063-023-07202-6 |
Ejemplares similares
-
Binary-state speciation and extinction method is conditionally robust to realistic violations of its assumptions
por: Simpson, Andrew G., et al.
Publicado: (2018) -
Guidance for using pilot studies to inform the design of intervention trials with continuous outcomes
por: Bell, Melanie L, et al.
Publicado: (2018) -
Evaluating assumptions of definition-based pulmonary exacerbation endpoints in cystic fibrosis clinical trials
por: VanDevanter, Donald R., et al.
Publicado: (2021) -
An investigation of the constancy of effect in Cochrane systematic reviews in context with the assumptions for noninferiority trials
por: Duro, Enass M., et al.
Publicado: (2022) -
An investigation of the impact of futility analysis in publicly funded trials
por: Sully, Benjamin GO, et al.
Publicado: (2014)