Oncogenic Merkel Cell Polyomavirus T Antigen Truncating Mutations are Mediated by APOBEC3 Activity in Merkel Cell Carcinoma

Merkel cell carcinoma (MCC) is an aggressive skin cancer, which is frequently caused by Merkel cell polyomavirus (MCPyV). Mutations of MCPyV tumor (T) antigens are major pathologic events of virus-positive (MCPyV+) MCCs, but their source is unclear. Activation-induced cytidine deaminase (AID)/APOBEC...

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Detalles Bibliográficos
Autores principales: Soikkeli, Anni I., Kyläniemi, Minna K., Sihto, Harri, Alinikula, Jukka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10035372/
https://www.ncbi.nlm.nih.gov/pubmed/36970060
http://dx.doi.org/10.1158/2767-9764.CRC-22-0211

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