Cargando…
Clinical Pharmacology and Determinants of Response to UCART19, an Allogeneic Anti-CD19 CAR-T Cell Product, in Adult B-cell Acute Lymphoblastic Leukemia
BACKGROUND: UCART19 is an “off-the-shelf” genome-edited anti-CD19 chimeric antigen receptor (CAR)-T cell product, manufactured from unrelated healthy donor cells. METHODS: UCART19 was administered to 25 adult patients with relapsed or refractory (R/R) B-cell acute lymphoblastic leukemia (B-ALL) in t...
Autores principales: | Dupouy, Sandra, Marchiq, Ibtissam, Derippe, Thibaud, Almena-Carrasco, Maria, Jozwik, Agnieszka, Fouliard, Sylvain, Adimy, Yasmina, Geronimi, Julia, Graham, Charlotte, Jain, Nitin, Maus, Marcela V., Mohty, Mohamad, Boissel, Nicolas, Teshima, Takanori, Kato, Koji, Benjamin, Reuben, Balandraud, Svetlana |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for Cancer Research
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10035397/ https://www.ncbi.nlm.nih.gov/pubmed/36970059 http://dx.doi.org/10.1158/2767-9764.CRC-22-0175 |
Ejemplares similares
-
Mechanistic Modeling of the Interplay Between Host Immune System, IL-7 and UCART19 Allogeneic CAR-T Cells in Adult B-cell Acute Lymphoblastic Leukemia
por: Derippe, Thibaud, et al.
Publicado: (2022) -
Gene-edited healthy donor CAR T cells show superior anti-tumour activity compared to CAR T cells derived from patients with lymphoma in an in vivo model of high-grade lymphoma
por: Graham, Charlotte Elizabeth, et al.
Publicado: (2021) -
P1408: UPDATED RESULTS OF THE PHASE I BALLI-01 TRIAL OF UCART22, AN ANTI-CD22 ALLOGENEIC CAR-T CELL PRODUCT, IN PATIENTS WITH RELAPSED OR REFRACTORY (R/R) CD22+ B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA (B-ALL)
por: Boissel, Nicolas, et al.
Publicado: (2023) -
P1420: PRE-CLINICAL PROOF OF CONCEPT DEMONSTRATES ROBUST ACTIVITY OF UCART20X22 DUAL CAR T-CELLS FOR THE TREATMENT OF B-CELL MALIGNANCIES
por: Aranda Orgilles, B., et al.
Publicado: (2022) -
Hypoxia, cancer metabolism and the therapeutic benefit of targeting lactate/H(+) symporters
por: Marchiq, Ibtissam, et al.
Publicado: (2015)