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MEK5-ERK5 Axis Promotes Self-renewal and Tumorigenicity of Glioma Stem Cells

Glioma stem cells (GSC) promote the malignancy of glioblastoma (GBM), the most lethal brain tumor. ERK5 belongs to the MAPK family. Here, we demonstrated that MAPK kinase 5 (MEK5)-ERK5-STAT3 pathway plays an essential role in maintaining GSC stemness and tumorigenicity by integrating genetic and pha...

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Detalles Bibliográficos
Autores principales:	Fukasawa, Kazuya, Lyu, Jiajun, Kubo, Takuya, Tanaka, Yuki, Suzuki, Akane, Horie, Tetsuhiro, Tomizawa, Akane, Osumi, Ryoma, Iwahashi, Sayuki, Tokumura, Kazuya, Murata, Misato, Kobayashi, Masaki, Todo, Tomoki, Hirao, Atsushi, Hinoi, Eiichi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10035453/ https://www.ncbi.nlm.nih.gov/pubmed/36968222 http://dx.doi.org/10.1158/2767-9764.CRC-22-0243

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