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Inactivation of Notch4 Attenuated Pancreatic Tumorigenesis in Mice

Expression of the Notch family of receptors is often upregulated in pancreatic ductal adenocarcinoma (PDAC). In this study, we focused on Notch4, which had not been investigated in PDAC. We generated KC (LSL-Kras(G12D);p48-Cre), N4(−)(/)(−)KC (Notch4(−)(/)(−);LSL-Kras(G12D);p48-Cre), PKC (p16(fl/fl)...

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Detalles Bibliográficos
Autores principales:	Saeki, Kiyoshi, Qiu, Wanglong, Friedman, Richard A., Pan, Samuel, Lu, Jordan, Ichimiya, Shu, Chio, Iok In Christine, Shawber, Carrie J., Kitajewski, Jan, Hu, Jianhua, Su, Gloria H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10035463/ https://www.ncbi.nlm.nih.gov/pubmed/36970723 http://dx.doi.org/10.1158/2767-9764.CRC-22-0106

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