Loss of Dok-3 in Non-tumor Cells Induces Malignant Transformation of Benign Epithelial Tumor Cells of the Intestine

The fundamental difference between benign and malignant tumors lies in their invasive ability. It is believed that malignant conversion of benign tumor cells is induced by a tumor cell–intrinsic accumulation of driver gene mutations. Here, we found that disruption of the Dok-3 tumor suppressor gene...

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Detalles Bibliográficos
Autores principales: Arimura, Sumimasa, Inoue-Yamauchi, Akane, Katayama, Kotoe, Kanno, Tatsuo, Jozawa, Hiroki, Imoto, Seiya, Yamanashi, Yuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10035524/
https://www.ncbi.nlm.nih.gov/pubmed/36970719
http://dx.doi.org/10.1158/2767-9764.CRC-22-0347

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