Early Experience of Oncolytic Virus Injection Combined with Sorafenib in a Patient with Advanced Hepatocellular Carcinoma and Portal Vein Thrombosis

JX-594 is a modified oncolytic poxvirus designed to selectively replicate in and destroy cancer cells. In a pilot study, JX-594 injection followed by sorafenib was well-tolerated in three patients and associated with objective tumor responses. In this study, we report a case in which a patient with...

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Autores principales: Jo, Hyun Ho, Chun, Seong Joon, Yoo, Jeong-Ju, Lee, Min Hee, Kim, Sang Gyune, Kim, Young Seok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Liver Cancer Association 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10035676/
https://www.ncbi.nlm.nih.gov/pubmed/37384323
http://dx.doi.org/10.17998/jlc.20.2.177
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author Jo, Hyun Ho
Chun, Seong Joon
Yoo, Jeong-Ju
Lee, Min Hee
Kim, Sang Gyune
Kim, Young Seok
author_facet Jo, Hyun Ho
Chun, Seong Joon
Yoo, Jeong-Ju
Lee, Min Hee
Kim, Sang Gyune
Kim, Young Seok
author_sort Jo, Hyun Ho
collection PubMed
description JX-594 is a modified oncolytic poxvirus designed to selectively replicate in and destroy cancer cells. In a pilot study, JX-594 injection followed by sorafenib was well-tolerated in three patients and associated with objective tumor responses. In this study, we report a case in which a patient with advanced hepatocellular carcinoma and portal vein thrombosis was treated with a combination of JX-594 and sorafenib.
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spelling pubmed-100356762023-06-28 Early Experience of Oncolytic Virus Injection Combined with Sorafenib in a Patient with Advanced Hepatocellular Carcinoma and Portal Vein Thrombosis Jo, Hyun Ho Chun, Seong Joon Yoo, Jeong-Ju Lee, Min Hee Kim, Sang Gyune Kim, Young Seok J Liver Cancer Case Report JX-594 is a modified oncolytic poxvirus designed to selectively replicate in and destroy cancer cells. In a pilot study, JX-594 injection followed by sorafenib was well-tolerated in three patients and associated with objective tumor responses. In this study, we report a case in which a patient with advanced hepatocellular carcinoma and portal vein thrombosis was treated with a combination of JX-594 and sorafenib. Korean Liver Cancer Association 2020-09 2020-09-30 /pmc/articles/PMC10035676/ /pubmed/37384323 http://dx.doi.org/10.17998/jlc.20.2.177 Text en Copyright © 2020 by The Korean Liver Cancer Association https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Jo, Hyun Ho
Chun, Seong Joon
Yoo, Jeong-Ju
Lee, Min Hee
Kim, Sang Gyune
Kim, Young Seok
Early Experience of Oncolytic Virus Injection Combined with Sorafenib in a Patient with Advanced Hepatocellular Carcinoma and Portal Vein Thrombosis
title Early Experience of Oncolytic Virus Injection Combined with Sorafenib in a Patient with Advanced Hepatocellular Carcinoma and Portal Vein Thrombosis
title_full Early Experience of Oncolytic Virus Injection Combined with Sorafenib in a Patient with Advanced Hepatocellular Carcinoma and Portal Vein Thrombosis
title_fullStr Early Experience of Oncolytic Virus Injection Combined with Sorafenib in a Patient with Advanced Hepatocellular Carcinoma and Portal Vein Thrombosis
title_full_unstemmed Early Experience of Oncolytic Virus Injection Combined with Sorafenib in a Patient with Advanced Hepatocellular Carcinoma and Portal Vein Thrombosis
title_short Early Experience of Oncolytic Virus Injection Combined with Sorafenib in a Patient with Advanced Hepatocellular Carcinoma and Portal Vein Thrombosis
title_sort early experience of oncolytic virus injection combined with sorafenib in a patient with advanced hepatocellular carcinoma and portal vein thrombosis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10035676/
https://www.ncbi.nlm.nih.gov/pubmed/37384323
http://dx.doi.org/10.17998/jlc.20.2.177
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