Characterization of the Tau Interactome in Human Brain Reveals Isoform-Dependent Interaction with 14-3-3 Family Proteins

Despite exhibiting tau phosphorylation similar to Alzheimer’s disease (AD), the human fetal brain is remarkably resilient to tau aggregation and toxicity. To identify potential mechanisms for this resilience, we used co-immunoprecipitation (co-IP) with mass spectrometry to characterize the tau inter...

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Detalles Bibliográficos
Autores principales: Betters, Ryan K., Luhmann, Emma, Gottschalk, Amy C., Xu, Zhen, Shin, Mallory R., Ptak, Christopher P., Fiock, Kimberly L., Radoshevich, Lilliana C., Hefti, Marco M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2023
Materias:
Research Article: New Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10035768/
https://www.ncbi.nlm.nih.gov/pubmed/36898832
http://dx.doi.org/10.1523/ENEURO.0503-22.2023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10035768/
https://www.ncbi.nlm.nih.gov/pubmed/36898832
http://dx.doi.org/10.1523/ENEURO.0503-22.2023

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