p27(Kip1) V109G as a biomarker for CDK4/6 inhibitors indication in hormone receptor–positive breast cancer

CDK4/6 inhibitors benefit a minority of patients who receive them in the breast cancer adjuvant setting. p27(Kip1) is a protein that inhibits CDK/Cyclin complexes. We hypothesized that single-nucleotide polymorphisms that impaired p27(Kip1) function could render patients refractory to endocrine ther...

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Detalles Bibliográficos
Autores principales: Mouron, Silvana, Bueno, Maria J, Muñoz, Manuel, Torres, Raul, Rodríguez, Sandra, Apala, Juan V, Silva, Jorge, Sánchez-Bayona, Rodrigo, Manso, Luis, Guerra, Juan, Rodriguez-Lajusticia, Laura, Malon, Diego, Malumbres, Marcos, Quintela-Fandino, Miguel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Brief Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10035773/
https://www.ncbi.nlm.nih.gov/pubmed/36806942
http://dx.doi.org/10.1093/jncics/pkad014

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