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Dynamics of two-step reversible enzymatic reaction under fractional derivative with Mittag-Leffler Kernel

Chemical kinetics is a branch of chemistry that is founded on understanding chemical reaction rates. Chemical kinetics relates many aspects of cosmology, geology, and even in some cases of, psychology. There is a need for mathematical modelling of these chemical reactions. Therefore, the present res...

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Autores principales: Khan, Maryam, Ahmad, Zubair, Ali, Farhad, Khan, Naveed, Khan, Ilyas, Nisar, Kottakkaran Sooppy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10035869/
https://www.ncbi.nlm.nih.gov/pubmed/36952579
http://dx.doi.org/10.1371/journal.pone.0277806
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author Khan, Maryam
Ahmad, Zubair
Ali, Farhad
Khan, Naveed
Khan, Ilyas
Nisar, Kottakkaran Sooppy
author_facet Khan, Maryam
Ahmad, Zubair
Ali, Farhad
Khan, Naveed
Khan, Ilyas
Nisar, Kottakkaran Sooppy
author_sort Khan, Maryam
collection PubMed
description Chemical kinetics is a branch of chemistry that is founded on understanding chemical reaction rates. Chemical kinetics relates many aspects of cosmology, geology, and even in some cases of, psychology. There is a need for mathematical modelling of these chemical reactions. Therefore, the present research is based on chemical kinetics-based modelling and dynamics of enzyme processes. This research looks at the two-step substrate-enzyme reversible response. In the two step-reversible reactions, substrate combines with enzymes which is further converted into products with two steps. The model is displayed through the flow chart, which is then transformed into ODEs. The Atangana-Baleanu time-fractional operator and the Mittag-Leffler kernel are used to convert the original set of highly nonlinear coupled integer order ordinary differential equations into a fractional-order model. Additionally, it is shown that the solution to the investigated fractional model is unique, limited, and may be represented by its response velocity. A numerical scheme, also known as the Atangana-Toufik method, based on Newton polynomial interpolation technique via MATLAB software, is adopted to find the graphical results. The dynamics of reaction against different reaction rates are presented through various figures. It is observed that the forward reaction rates increase the reaction speed while backward reaction rates reduce it.
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spelling pubmed-100358692023-03-24 Dynamics of two-step reversible enzymatic reaction under fractional derivative with Mittag-Leffler Kernel Khan, Maryam Ahmad, Zubair Ali, Farhad Khan, Naveed Khan, Ilyas Nisar, Kottakkaran Sooppy PLoS One Research Article Chemical kinetics is a branch of chemistry that is founded on understanding chemical reaction rates. Chemical kinetics relates many aspects of cosmology, geology, and even in some cases of, psychology. There is a need for mathematical modelling of these chemical reactions. Therefore, the present research is based on chemical kinetics-based modelling and dynamics of enzyme processes. This research looks at the two-step substrate-enzyme reversible response. In the two step-reversible reactions, substrate combines with enzymes which is further converted into products with two steps. The model is displayed through the flow chart, which is then transformed into ODEs. The Atangana-Baleanu time-fractional operator and the Mittag-Leffler kernel are used to convert the original set of highly nonlinear coupled integer order ordinary differential equations into a fractional-order model. Additionally, it is shown that the solution to the investigated fractional model is unique, limited, and may be represented by its response velocity. A numerical scheme, also known as the Atangana-Toufik method, based on Newton polynomial interpolation technique via MATLAB software, is adopted to find the graphical results. The dynamics of reaction against different reaction rates are presented through various figures. It is observed that the forward reaction rates increase the reaction speed while backward reaction rates reduce it. Public Library of Science 2023-03-23 /pmc/articles/PMC10035869/ /pubmed/36952579 http://dx.doi.org/10.1371/journal.pone.0277806 Text en © 2023 Khan et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Khan, Maryam
Ahmad, Zubair
Ali, Farhad
Khan, Naveed
Khan, Ilyas
Nisar, Kottakkaran Sooppy
Dynamics of two-step reversible enzymatic reaction under fractional derivative with Mittag-Leffler Kernel
title Dynamics of two-step reversible enzymatic reaction under fractional derivative with Mittag-Leffler Kernel
title_full Dynamics of two-step reversible enzymatic reaction under fractional derivative with Mittag-Leffler Kernel
title_fullStr Dynamics of two-step reversible enzymatic reaction under fractional derivative with Mittag-Leffler Kernel
title_full_unstemmed Dynamics of two-step reversible enzymatic reaction under fractional derivative with Mittag-Leffler Kernel
title_short Dynamics of two-step reversible enzymatic reaction under fractional derivative with Mittag-Leffler Kernel
title_sort dynamics of two-step reversible enzymatic reaction under fractional derivative with mittag-leffler kernel
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10035869/
https://www.ncbi.nlm.nih.gov/pubmed/36952579
http://dx.doi.org/10.1371/journal.pone.0277806
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