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Physical and biological dosimetric margin according to prescription method for stereotactic body radiation therapy

This study aimed to expand the biological conversion factor (BCF) model, which converts the physical dosimetric margin (PDM) to the biological dosimetric margin (BDM) for point prescription with 3-dimensional conformal radiation therapy (3DCRT) and the marginal prescription method with volumetric-mo...

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Autores principales: Kawahara, Daisuke, Saito, Akito, Nagata, Yasushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036100/
https://www.ncbi.nlm.nih.gov/pubmed/36626670
http://dx.doi.org/10.1093/jrr/rrac097
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author Kawahara, Daisuke
Saito, Akito
Nagata, Yasushi
author_facet Kawahara, Daisuke
Saito, Akito
Nagata, Yasushi
author_sort Kawahara, Daisuke
collection PubMed
description This study aimed to expand the biological conversion factor (BCF) model, which converts the physical dosimetric margin (PDM) to the biological dosimetric margin (BDM) for point prescription with 3-dimensional conformal radiation therapy (3DCRT) and the marginal prescription method with volumetric-modulated arc radiotherapy (VMAT). The VMAT of the marginal prescription and the 3DCRT of the point prescription with lung stereotactic body radiation therapy (SBRT) by using RayStation were planned. The biological equivalent dose (BED) for a dose per fraction (DPF) of 3–20 Gy was calculated from these plans. The dose was perturbed with the calculation using a 1-mm step isocenter shift. The dose covering 95% of the target was greater than or equal to 90% of the prescribed physical dose, and the BED were defined as the PDM and BDM, respectively. The BCF was created as a function of the DPF. The PDM and BDM for all DPFs were larger with the point prescription method than with the marginal prescription method. The marginal prescription method with a 60% isodose line had a larger PDM and BDM. The BCF with the point prescription was smaller than that with the marginal prescription in the left–right (LR), anterior–posterior (AP) and cranio–caudal (CC) directions. In the marginal prescription method, the 60% isodose line had a higher BCF. In conclusion, the improved BCF method could be converted to BDM for point prescription with 3DCRT and marginal prescription method with VMAT, which is required for stereotactic radiation therapy in radiobiology-based treatment planning.
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spelling pubmed-100361002023-03-24 Physical and biological dosimetric margin according to prescription method for stereotactic body radiation therapy Kawahara, Daisuke Saito, Akito Nagata, Yasushi J Radiat Res Regular paper This study aimed to expand the biological conversion factor (BCF) model, which converts the physical dosimetric margin (PDM) to the biological dosimetric margin (BDM) for point prescription with 3-dimensional conformal radiation therapy (3DCRT) and the marginal prescription method with volumetric-modulated arc radiotherapy (VMAT). The VMAT of the marginal prescription and the 3DCRT of the point prescription with lung stereotactic body radiation therapy (SBRT) by using RayStation were planned. The biological equivalent dose (BED) for a dose per fraction (DPF) of 3–20 Gy was calculated from these plans. The dose was perturbed with the calculation using a 1-mm step isocenter shift. The dose covering 95% of the target was greater than or equal to 90% of the prescribed physical dose, and the BED were defined as the PDM and BDM, respectively. The BCF was created as a function of the DPF. The PDM and BDM for all DPFs were larger with the point prescription method than with the marginal prescription method. The marginal prescription method with a 60% isodose line had a larger PDM and BDM. The BCF with the point prescription was smaller than that with the marginal prescription in the left–right (LR), anterior–posterior (AP) and cranio–caudal (CC) directions. In the marginal prescription method, the 60% isodose line had a higher BCF. In conclusion, the improved BCF method could be converted to BDM for point prescription with 3DCRT and marginal prescription method with VMAT, which is required for stereotactic radiation therapy in radiobiology-based treatment planning. Oxford University Press 2023-01-10 /pmc/articles/PMC10036100/ /pubmed/36626670 http://dx.doi.org/10.1093/jrr/rrac097 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of The Japanese Radiation Research Society and Japanese Society for Radiation Oncology. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Regular paper
Kawahara, Daisuke
Saito, Akito
Nagata, Yasushi
Physical and biological dosimetric margin according to prescription method for stereotactic body radiation therapy
title Physical and biological dosimetric margin according to prescription method for stereotactic body radiation therapy
title_full Physical and biological dosimetric margin according to prescription method for stereotactic body radiation therapy
title_fullStr Physical and biological dosimetric margin according to prescription method for stereotactic body radiation therapy
title_full_unstemmed Physical and biological dosimetric margin according to prescription method for stereotactic body radiation therapy
title_short Physical and biological dosimetric margin according to prescription method for stereotactic body radiation therapy
title_sort physical and biological dosimetric margin according to prescription method for stereotactic body radiation therapy
topic Regular paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036100/
https://www.ncbi.nlm.nih.gov/pubmed/36626670
http://dx.doi.org/10.1093/jrr/rrac097
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