Cargando…

Targeting MLL Methyltransferases Enhances the Antitumor Effects of PI3K Inhibition in Hormone Receptor–positive Breast Cancer

The high frequency of aberrant PI3K pathway activation in hormone receptor–positive (HR(+)) breast cancer has led to the development, clinical testing, and approval of the p110α-selective PI3K inhibitor alpelisib. The limited clinical efficacy of alpelisib and other PI3K inhibitors is partially attr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jones, Robert B., Farhi, Jonathan, Adams, Miranda, Parwani, Kiran K., Cooper, Garrett W., Zecevic, Milica, Lee, Richard S., Hong, Andrew L., Spangle, Jennifer M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036132/ https://www.ncbi.nlm.nih.gov/pubmed/36970726 http://dx.doi.org/10.1158/2767-9764.CRC-22-0158

Ejemplares similares

H3.3K4M destabilizes enhancer H3K4 methyltransferases MLL3/MLL4 and impairs adipose tissue development
por: Jang, Younghoon, et al.
Publicado: (2019)

Histone H3 E50K mutation confers oncogenic activity and supports an EMT phenotype
por: Sad, K, et al.
Publicado: (2023)

The Histone Methyltransferase Activity of MLL1 Is Dispensable for Hematopoiesis and Leukemogenesis
por: Mishra, Bibhu P., et al.
Publicado: (2014)

The MLL3/4 H3K4 methyltransferase complex in establishing an active enhancer landscape
por: Wang, Lan-Hsin, et al.
Publicado: (2021)

MLL3 and MLL4 Methyltransferases Bind to the MAFA and MAFB Transcription Factors to Regulate Islet β-Cell Function
por: Scoville, David W., et al.
Publicado: (2015)

FOXA1 Directs H3K4 Monomethylation at Enhancers via Recruitment of the Methyltransferase MLL3
por: Jozwik, Kamila M., et al.
Publicado: (2016)

MLL methyltransferases regulate H3K4 methylation to ensure CENP-A assembly at human centromeres
por: Malik, Kausika Kumar, et al.
Publicado: (2023)

The histone H3-lysine 4-methyltransferase Mll4 regulates the development of growth hormone-releasing hormone-producing neurons in the mouse hypothalamus
por: Huisman, Christian, et al.
Publicado: (2021)

Pax6 associates with H3K4-specific histone methyltransferases Mll1, Mll2, and Set1a and regulates H3K4 methylation at promoters and enhancers
por: Sun, Jian, et al.
Publicado: (2016)

Circadian clock function does not require the histone methyltransferase MLL3
por: Baxter, Matthew, et al.
Publicado: (2022)

Mutations in Mll2, an H3K4 Methyltransferase, Result in Insulin Resistance and Impaired Glucose Tolerance in Mice
por: Goldsworthy, Michelle, et al.
Publicado: (2013)

H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation
por: Lee, Ji-Eun, et al.
Publicado: (2013)

Targeting Mll1 H3K4 methyltransferase activity to guide cardiac lineage specific reprogramming of fibroblasts
por: Liu, Liu, et al.
Publicado: (2016)

Why are so many MLL lysine methyltransferases required for normal mammalian development?
por: Crump, Nicholas T., et al.
Publicado: (2019)

Epigenetic regulation of planarian stem cells by the SET1/MLL family of histone methyltransferases
por: Hubert, Amy, et al.
Publicado: (2013)

Regulation of DNA replication and chromosomal polyploidy by the MLL-WDR5-RBBP5 methyltransferases
por: Lu, Fei, et al.
Publicado: (2016)

The internal interaction in RBBP5 regulates assembly and activity of MLL1 methyltransferase complex
por: Han, Jianming, et al.
Publicado: (2019)

Structure, Activity and Function of the MLL2 (KMT2B) Protein Lysine Methyltransferase
por: Klonou, Alexia, et al.
Publicado: (2021)

An Ash2L/RbBP5 Heterodimer Stimulates the MLL1 Methyltransferase Activity through Coordinated Substrate Interactions with the MLL1 SET Domain
por: Cao, Fang, et al.
Publicado: (2010)

A PTIP–PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex
por: Starnes, Linda M., et al.
Publicado: (2016)

The histone 3 lysine 4 methyltransferase, Mll2, is only required briefly in development and spermatogenesis
por: Glaser, Stefan, et al.
Publicado: (2009)

Histone H3K36me2-Specific Methyltransferase ASH1L Promotes MLL-AF9-Induced Leukemogenesis
por: Aljazi, Mohammad B., et al.
Publicado: (2021)

Chemical sensors for imaging total cellular aliphatic aldehydes in live cells
por: Wills, Rachel, et al.
Publicado: (2023)

The lysine‐specific methyltransferase KMT2C/MLL3 regulates DNA repair components in cancer
por: Rampias, Theodoros, et al.
Publicado: (2019)

Targeting the histone H3 lysine 79 methyltransferase DOT1L in MLL-rearranged leukemias
por: Yi, Yan, et al.
Publicado: (2022)

The histone methyltransferase MLL1/KMT2A in monocytes drives coronavirus-associated coagulopathy and inflammation
por: Sharma, Sriganesh B., et al.
Publicado: (2023)

EBF1 drives hallmark B cell gene expression by enabling the interaction of PAX5 with the MLL H3K4 methyltransferase complex
por: Bullerwell, Charles E., et al.
Publicado: (2021)

Distinct kinetic mechanisms of H3K4 methylation catalyzed by MLL3 and MLL4 core complexes
por: Zheng, Yongxin, et al.
Publicado: (2021)

The metabolic sensor PASK is a histone 3 kinase that also regulates H3K4 methylation by associating with H3K4 MLL2 methyltransferase complex
por: Karakkat, Jimsheena V, et al.
Publicado: (2019)

Association of the histone-lysine N-methyltransferase MLL5 gene with coronary artery disease in Chinese Han people
por: Yuan, Qinghua, et al.
Publicado: (2014)

Selective binding of the PHD6 finger of MLL4 to histone H4K16ac links MLL4 and MOF
por: Zhang, Yi, et al.
Publicado: (2019)

MLL4 Regulates the Progression of Non–Small-Cell Lung Cancer by Regulating the PI3K/AKT/SOX2 Axis
por: Yang, Yang, et al.
Publicado: (2023)

Histone Methyltransferase MLL1 Mediates Oxidative Stress and Apoptosis upon Deoxynivalenol Exposure in the Intestinal Porcine Epithelial Cells
por: Shi, Dongfeng, et al.
Publicado: (2022)

PI3K-regulated Glycine N-methyltransferase is required for the development of prostate cancer
por: Zabala-Letona, Amaia, et al.
Publicado: (2022)

DPY30 acts as an ASH2L-specific stabilizer to stimulate the enzyme activity of MLL family methyltransferases on different substrates
por: Zhao, Lijie, et al.
Publicado: (2022)

Regulation of transcription by the MLL2 complex and MLL complex-associated AKAP95
por: Jiang, Hao, et al.
Publicado: (2013)

Enhanced antitumor immunity through sequential targeting of PI3Kδ and LAG3
por: Lauder, Sarah Nicol, et al.
Publicado: (2020)

Ordering of mutations in acute myeloid leukemia with partial tandem duplication of MLL (MLL-PTD)
por: Sun, Q-Y, et al.
Publicado: (2017)

Essential Functions of MLL1 and MLL2 in Retinal Development and Cone Cell Maintenance
por: Sun, Chi, et al.
Publicado: (2022)

Medulloblastoma and the DNA Damage Response
por: McSwain, Leon F., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_cnsdk18tdhh1kjdhbfn1dn8lur