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Bone Mineral Density in Patients with Pediatric Inflammatory Bowel Disease Using Dual Energy X-Ray Absorptiometry

BACKGROUND: Inflammatory bowel disease (IBD) is a chronic inflammatory immune-mediated condition that affects the gastrointestinal system and alters bone growth and bone mineral density (BMD). Here we aimed to study the prevalence and predictors of a low BMD in pediatric patients with IBD. METHODS:...

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Autores principales: Isa, Hasan M., Ezzaldin, Amira A., Alabbasi, Mohamed M., ALaazmi, Noora H., Masood, Abdulrahman S., Alabbasi, Hissa M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society for Bone and Mineral Research 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036179/
https://www.ncbi.nlm.nih.gov/pubmed/36950841
http://dx.doi.org/10.11005/jbm.2023.30.1.59
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author Isa, Hasan M.
Ezzaldin, Amira A.
Alabbasi, Mohamed M.
ALaazmi, Noora H.
Masood, Abdulrahman S.
Alabbasi, Hissa M.
author_facet Isa, Hasan M.
Ezzaldin, Amira A.
Alabbasi, Mohamed M.
ALaazmi, Noora H.
Masood, Abdulrahman S.
Alabbasi, Hissa M.
author_sort Isa, Hasan M.
collection PubMed
description BACKGROUND: Inflammatory bowel disease (IBD) is a chronic inflammatory immune-mediated condition that affects the gastrointestinal system and alters bone growth and bone mineral density (BMD). Here we aimed to study the prevalence and predictors of a low BMD in pediatric patients with IBD. METHODS: This retrospective cross-sectional analytical study included pediatric patients with IBD in whom BMD was evaluated using dual energy X-ray absorptiometry of the total body and lumbar spine. Osteoporosis was defined as a BMD Z-score ≤−2, osteopenia as −2 to −1, and normal as >−1. Clinical and laboratory findings were compared between patients with and without osteoporosis. RESULTS: Of the 48 patients, 30 (62.5%) were males, 35 (72.9%) had Crohn’s disease, and 13 (27.1%) had ulcerative colitis. The mean age at diagnosis was 9.9±2.8 years. The median age at the time of the BMD scans was 11.9 (interquartile range, 9.9–14.3) years. Total body BMD scans identified 13 (27.1%) and 16 (33.3%) patients with osteoporosis and osteopenia, respectively. Spinal BMD scans revealed that 17 (39.5%) and 14 (32.6%) patients had osteoporosis and osteopenia, respectively. A low body mass index (BMI) Z-score (P=0.038), ileocolonic disease location (P=0.008), and a low calcium level (P=0.008) were significant predictors of osteoporosis on the total body BMD scans. A low BMI Z-score (P=0.039), decreased hemoglobin level (P=0.018), low calcium level (P=0.033), and infliximab use (P=0.019) were significant predictors of osteoporosis on the spinal BMD scans. CONCLUSIONS: This study showed a high prevalence of low BMD among pediatric patients with IBD. A low BMI, ileocolonic disease location, low hemoglobin and calcium levels, and infliximab use were significantly associated with osteoporosis.
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spelling pubmed-100361792023-03-24 Bone Mineral Density in Patients with Pediatric Inflammatory Bowel Disease Using Dual Energy X-Ray Absorptiometry Isa, Hasan M. Ezzaldin, Amira A. Alabbasi, Mohamed M. ALaazmi, Noora H. Masood, Abdulrahman S. Alabbasi, Hissa M. J Bone Metab Original Article BACKGROUND: Inflammatory bowel disease (IBD) is a chronic inflammatory immune-mediated condition that affects the gastrointestinal system and alters bone growth and bone mineral density (BMD). Here we aimed to study the prevalence and predictors of a low BMD in pediatric patients with IBD. METHODS: This retrospective cross-sectional analytical study included pediatric patients with IBD in whom BMD was evaluated using dual energy X-ray absorptiometry of the total body and lumbar spine. Osteoporosis was defined as a BMD Z-score ≤−2, osteopenia as −2 to −1, and normal as >−1. Clinical and laboratory findings were compared between patients with and without osteoporosis. RESULTS: Of the 48 patients, 30 (62.5%) were males, 35 (72.9%) had Crohn’s disease, and 13 (27.1%) had ulcerative colitis. The mean age at diagnosis was 9.9±2.8 years. The median age at the time of the BMD scans was 11.9 (interquartile range, 9.9–14.3) years. Total body BMD scans identified 13 (27.1%) and 16 (33.3%) patients with osteoporosis and osteopenia, respectively. Spinal BMD scans revealed that 17 (39.5%) and 14 (32.6%) patients had osteoporosis and osteopenia, respectively. A low body mass index (BMI) Z-score (P=0.038), ileocolonic disease location (P=0.008), and a low calcium level (P=0.008) were significant predictors of osteoporosis on the total body BMD scans. A low BMI Z-score (P=0.039), decreased hemoglobin level (P=0.018), low calcium level (P=0.033), and infliximab use (P=0.019) were significant predictors of osteoporosis on the spinal BMD scans. CONCLUSIONS: This study showed a high prevalence of low BMD among pediatric patients with IBD. A low BMI, ileocolonic disease location, low hemoglobin and calcium levels, and infliximab use were significantly associated with osteoporosis. The Korean Society for Bone and Mineral Research 2023-02 2023-02-28 /pmc/articles/PMC10036179/ /pubmed/36950841 http://dx.doi.org/10.11005/jbm.2023.30.1.59 Text en Copyright © 2023 The Korean Society for Bone and Mineral Research https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Isa, Hasan M.
Ezzaldin, Amira A.
Alabbasi, Mohamed M.
ALaazmi, Noora H.
Masood, Abdulrahman S.
Alabbasi, Hissa M.
Bone Mineral Density in Patients with Pediatric Inflammatory Bowel Disease Using Dual Energy X-Ray Absorptiometry
title Bone Mineral Density in Patients with Pediatric Inflammatory Bowel Disease Using Dual Energy X-Ray Absorptiometry
title_full Bone Mineral Density in Patients with Pediatric Inflammatory Bowel Disease Using Dual Energy X-Ray Absorptiometry
title_fullStr Bone Mineral Density in Patients with Pediatric Inflammatory Bowel Disease Using Dual Energy X-Ray Absorptiometry
title_full_unstemmed Bone Mineral Density in Patients with Pediatric Inflammatory Bowel Disease Using Dual Energy X-Ray Absorptiometry
title_short Bone Mineral Density in Patients with Pediatric Inflammatory Bowel Disease Using Dual Energy X-Ray Absorptiometry
title_sort bone mineral density in patients with pediatric inflammatory bowel disease using dual energy x-ray absorptiometry
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036179/
https://www.ncbi.nlm.nih.gov/pubmed/36950841
http://dx.doi.org/10.11005/jbm.2023.30.1.59
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