Cargando…

Network-Based Method to Investigate the Promoted Cell Apoptosis Mechanisms of Oridonin in OSCC through the RNA-Transcriptome

The morbidity of oral cancer is high in the world. Oridonin is a traditional Chinese medicine that can effectively inhibit oral squamous cell carcinoma (OSCC) growth, but its mechanism remains unclear. Our previous data showed that oridonin inhibited CAL-27 cell proliferation and promoted apoptosis....

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Guohui, Guo, Yusheng, Liu, Yang, Cai, Xiangsheng, Deng, Tanggang, Pei, Tianchu, Huang, Long, Chen, Kai, Pan, Xuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036191/ https://www.ncbi.nlm.nih.gov/pubmed/36969496 http://dx.doi.org/10.1155/2023/5293677

Ejemplares similares

Intracellular Glutathione Depletion by Oridonin Leads to Apoptosis in Hepatic Stellate Cells
por: Kuo, Liang-Mou, et al.
Publicado: (2014)

Antiangiogenic effects of oridonin
por: Tian, Lili, et al.
Publicado: (2017)

Oridonin induces the apoptosis of metastatic hepatocellular carcinoma cells via a mitochondrial pathway
por: ZHU, MIN, et al.
Publicado: (2013)

Oridonin Induces Apoptosis of Laryngeal Carcinoma via Endoplasmic Reticulum Stress
por: Kou, Bo, et al.
Publicado: (2020)

Gene Expression in Uninvolved Oral Mucosa of OSCC Patients Facilitates Identification of Markers Predictive of OSCC Outcomes
por: Lohavanichbutr, Pawadee, et al.
Publicado: (2012)

Oridonin synergistically enhances JQ1-triggered apoptosis in hepatocellular cancer cells through mitochondrial pathway
por: Zhang, Hua-Peng, et al.
Publicado: (2017)

Investigation of the anti-asthmatic activity of Oridonin on a mouse model of asthma
por: Wang, Jing, et al.
Publicado: (2016)

Oridonin induces apoptosis in HGC-27 cells by activating the JNK signaling pathway
por: Ren, Dong-Lin, et al.
Publicado: (2020)

Oridonin Dose-Dependently Modulates the Cell Senescence and Apoptosis of Gastric Cancer Cells
por: Wang, Yiping, et al.
Publicado: (2021)

Oridonin protects against cardiac hypertrophy by promoting P21-related autophagy
por: Xu, Man, et al.
Publicado: (2019)

Oridonin Attenuates Burkholderia cenocepacia Virulence by Suppressing Quorum-Sensing Signaling
por: Li, Xia, et al.
Publicado: (2022)

Oridonin nanosuspension was more effective than free oridonin on G(2)/M cell cycle arrest and apoptosis in the human pancreatic cancer PANC-1 cell line
por: Qi, Xiaoli, et al.
Publicado: (2012)

Oridonin induces Mdm2‐p60 to promote p53‐mediated apoptosis and cell cycle arrest in neuroblastoma
por: Zhu, Han‐Qing, et al.
Publicado: (2019)

Molecular Insight in the Multifunctional Effects of Oridonin
por: Owona, Brice Ayissi, et al.
Publicado: (2015)

Preliminary safety assessment of oridonin in zebrafish
por: Tian, Lili, et al.
Publicado: (2019)

Influence of verapamil on the pharmacokinetics of oridonin in rats
por: Liu, Jing, et al.
Publicado: (2019)

Wnt/β-catenin signaling pathway is involved in induction of apoptosis by oridonin in colon cancer COLO205 cells
por: Bu, Heqi, et al.
Publicado: (2019)

Oridonin enhances the anti-tumor activity of gemcitabine towards pancreatic cancer by stimulating Bax- and Smac-dependent apoptosis
por: Liu, Dian-Lei, et al.
Publicado: (2020)

Structural modification of oridonin via DAST induced rearrangement
por: Luo, Dong-Dong, et al.
Publicado: (2018)

Exosomes derived from MSC pre‐treated with oridonin alleviates myocardial IR injury by suppressing apoptosis via regulating autophagy activation
por: Fu, Minghuan, et al.
Publicado: (2021)

Proline-Dependent Induction of Apoptosis in Oral Squamous Cell Carcinoma (OSCC)—The Effect of Celecoxib
por: Tołoczko-Iwaniuk, Natalia, et al.
Publicado: (2020)

Investigation of Metal-Organic Framework-5 (MOF-5) as an Antitumor Drug Oridonin Sustained Release Carrier
por: Chen, Gongsen, et al.
Publicado: (2019)

Oridonin induces apoptosis and senescence by increasing hydrogen peroxide and glutathione depletion in colorectal cancer cells
por: GAO, FENG-HOU, et al.
Publicado: (2012)

Oridonin induces apoptosis and cell cycle arrest of gallbladder cancer cells via the mitochondrial pathway
por: Bao, Runfa, et al.
Publicado: (2014)

Mitochondrial ROS contribute to oridonin-induced HepG2 apoptosis through PARP activation
por: Liu, Xiaoning, et al.
Publicado: (2018)

The CS1 segment of fibronectin is involved in human OSCC pathogenesis by mediating OSCC cell spreading, migration, and invasion
por: Kamarajan, Pachiyappan, et al.
Publicado: (2010)

Solubility and Bioavailability Enhancement of Oridonin: A Review
por: Zhang, Yuanyuan, et al.
Publicado: (2020)

Recent advances in oridonin derivatives with anticancer activity
por: Sobral, Pedro J. M., et al.
Publicado: (2023)

Qualitative and Quantitative Analysis of ROS-Mediated Oridonin-Induced Oesophageal Cancer KYSE-150 Cell Apoptosis by Atomic Force Microscopy
por: Pi, Jiang, et al.
Publicado: (2015)

Oridonin Promotes Apoptosis and Restrains the Viability and Migration of Bladder Cancer by Impeding TRPM7 Expression via the ERK and AKT Signaling Pathways
por: Che, Xianping, et al.
Publicado: (2021)

Cytoplasmic eIF6 promotes OSCC malignant behavior through AKT pathway
por: Zhao, Zechen, et al.
Publicado: (2021)

Antiviral Activity of Oridonin Against Herpes Simplex Virus Type 1
por: Jiang, Kai, et al.
Publicado: (2022)

Effects of oridonin nanosuspension on cell proliferation and apoptosis of human prostatic carcinoma PC-3 cell line
por: Zhang, Zhen, et al.
Publicado: (2010)

Oridonin Up-regulates Expression of P21 and Induces Autophagy and Apoptosis in Human Prostate Cancer Cells
por: Li, Xiang, et al.
Publicado: (2012)

Breastfeeding and childhood cancer risks: OSCC data
por: Lancashire, R J, et al.
Publicado: (2003)

Oridonin inhibits aberrant AKT activation in breast cancer
por: Sun, Bowen, et al.
Publicado: (2018)

Oridonin improves the therapeutic effect of lentinan on lung cancer
por: Gui, Yun, et al.
Publicado: (2021)

Oridonin: A Review of Its Pharmacology, Pharmacokinetics and Toxicity
por: Li, Xiang, et al.
Publicado: (2021)

Oridonin Delays Aging Through the AKT Signaling Pathway
por: An, Yongpan, et al.
Publicado: (2022)

Propofol induces apoptosis and ameliorates 5-fluorouracil resistance in OSCC cells by reducing the expression and secretion of amphiregulin
por: Yang, Kung-Ssu, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ue0ao4vqjm259ntmhnstf7r51n