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Expansion of human alpha‐cell area is associated with a higher maximum body mass index before the onset of type 2 diabetes
Highlights: We examined whether maximum body mass index (BMI) before the onset of diabetes (MBBO) affects histological findings of islet cells. We divided patients into two groups according to an MBBO cutoff of 25 kg/m(2) or BMI cutoff of 21 kg/m(2). We compared immunohistochemical parameters betwee...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Wiley Publishing Asia Pty Ltd
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036255/ https://www.ncbi.nlm.nih.gov/pubmed/36843206 http://dx.doi.org/10.1111/1753-0407.13370 |
| _version_ | 1784911610644529152 |
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| author | Ozawa, Harutoshi Fukui, Kenji Fujita, Yukari Ishibashi, Chisaki Yoneda, Sho Nammo, Takao Fujita, Shingo Baden, Megu Yamaguchi Kimura, Takekazu Tokunaga, Ayumi Kozawa, Junji Eguchi, Hidetoshi Shimomura, Iichiro |
| author_facet | Ozawa, Harutoshi Fukui, Kenji Fujita, Yukari Ishibashi, Chisaki Yoneda, Sho Nammo, Takao Fujita, Shingo Baden, Megu Yamaguchi Kimura, Takekazu Tokunaga, Ayumi Kozawa, Junji Eguchi, Hidetoshi Shimomura, Iichiro |
| author_sort | Ozawa, Harutoshi |
| collection | PubMed |
| description | Highlights: We examined whether maximum body mass index (BMI) before the onset of diabetes (MBBO) affects histological findings of islet cells. We divided patients into two groups according to an MBBO cutoff of 25 kg/m(2) or BMI cutoff of 21 kg/m(2). We compared immunohistochemical parameters between the MBBO groups or BMI groups. The relative alpha‐cell area in the high MBBO group was significantly higher than that in the low MBBO group. There was no difference in the other parameters between the MBBO groups or BMI groups. |
| format | Online Article Text |
| id | pubmed-10036255 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | Wiley Publishing Asia Pty Ltd |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-100362552023-03-25 Expansion of human alpha‐cell area is associated with a higher maximum body mass index before the onset of type 2 diabetes Ozawa, Harutoshi Fukui, Kenji Fujita, Yukari Ishibashi, Chisaki Yoneda, Sho Nammo, Takao Fujita, Shingo Baden, Megu Yamaguchi Kimura, Takekazu Tokunaga, Ayumi Kozawa, Junji Eguchi, Hidetoshi Shimomura, Iichiro J Diabetes Research Letter Highlights: We examined whether maximum body mass index (BMI) before the onset of diabetes (MBBO) affects histological findings of islet cells. We divided patients into two groups according to an MBBO cutoff of 25 kg/m(2) or BMI cutoff of 21 kg/m(2). We compared immunohistochemical parameters between the MBBO groups or BMI groups. The relative alpha‐cell area in the high MBBO group was significantly higher than that in the low MBBO group. There was no difference in the other parameters between the MBBO groups or BMI groups. Wiley Publishing Asia Pty Ltd 2023-02-26 /pmc/articles/PMC10036255/ /pubmed/36843206 http://dx.doi.org/10.1111/1753-0407.13370 Text en © 2023 The Authors. Journal of Diabetes published by Ruijin Hospital, Shanghai JiaoTong University School of Medicine and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Research Letter Ozawa, Harutoshi Fukui, Kenji Fujita, Yukari Ishibashi, Chisaki Yoneda, Sho Nammo, Takao Fujita, Shingo Baden, Megu Yamaguchi Kimura, Takekazu Tokunaga, Ayumi Kozawa, Junji Eguchi, Hidetoshi Shimomura, Iichiro Expansion of human alpha‐cell area is associated with a higher maximum body mass index before the onset of type 2 diabetes |
| title | Expansion of human alpha‐cell area is associated with a higher maximum body mass index before the onset of type 2 diabetes |
| title_full | Expansion of human alpha‐cell area is associated with a higher maximum body mass index before the onset of type 2 diabetes |
| title_fullStr | Expansion of human alpha‐cell area is associated with a higher maximum body mass index before the onset of type 2 diabetes |
| title_full_unstemmed | Expansion of human alpha‐cell area is associated with a higher maximum body mass index before the onset of type 2 diabetes |
| title_short | Expansion of human alpha‐cell area is associated with a higher maximum body mass index before the onset of type 2 diabetes |
| title_sort | expansion of human alpha‐cell area is associated with a higher maximum body mass index before the onset of type 2 diabetes |
| topic | Research Letter |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036255/ https://www.ncbi.nlm.nih.gov/pubmed/36843206 http://dx.doi.org/10.1111/1753-0407.13370 |
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