Imatinib blocks tyrosine phosphorylation of Smad4 and restores TGF-β growth-suppressive signaling in BCR-ABL1-positive leukemia

Loss of TGF-β-mediated growth suppression is a major contributor to the development of cancers, best exemplified by loss-of-function mutations in genes encoding components of the TGF-β signaling pathway in colorectal and pancreatic cancers. Alternatively, gain-of-function oncogene mutations can also...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Lijing, Gu, Shuchen, Chen, Fenfang, Yu, Yi, Cao, Jin, Li, Xinran, Gao, Chun, Chen, Yanzhen, Yuan, Shuchong, Liu, Xia, Qin, Jun, Zhao, Bin, Xu, Pinglong, Liang, Tingbo, Tong, Hongyan, Lin, Xia, Feng, Xin-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036327/
https://www.ncbi.nlm.nih.gov/pubmed/36959211
http://dx.doi.org/10.1038/s41392-023-01327-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036327/
https://www.ncbi.nlm.nih.gov/pubmed/36959211
http://dx.doi.org/10.1038/s41392-023-01327-5

Ejemplares similares