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High resolution propagation-based lung imaging at clinically relevant X-ray dose levels
Absorption-based clinical computed tomography (CT) is the current imaging method of choice in the diagnosis of lung diseases. Many pulmonary diseases are affecting microscopic structures of the lung, such as terminal bronchi, alveolar spaces, sublobular blood vessels or the pulmonary interstitial ti...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036329/ https://www.ncbi.nlm.nih.gov/pubmed/36959233 http://dx.doi.org/10.1038/s41598-023-30870-y |
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author | Albers, Jonas Wagner, Willi L. Fiedler, Mascha O. Rothermel, Anne Wünnemann, Felix Di Lillo, Francesca Dreossi, Diego Sodini, Nicola Baratella, Elisa Confalonieri, Marco Arfelli, Fulvia Kalenka, Armin Lotz, Joachim Biederer, Jürgen Wielpütz, Mark O. Kauczor, Hans-Ulrich Alves, Frauke Tromba, Giuliana Dullin, Christian |
author_facet | Albers, Jonas Wagner, Willi L. Fiedler, Mascha O. Rothermel, Anne Wünnemann, Felix Di Lillo, Francesca Dreossi, Diego Sodini, Nicola Baratella, Elisa Confalonieri, Marco Arfelli, Fulvia Kalenka, Armin Lotz, Joachim Biederer, Jürgen Wielpütz, Mark O. Kauczor, Hans-Ulrich Alves, Frauke Tromba, Giuliana Dullin, Christian |
author_sort | Albers, Jonas |
collection | PubMed |
description | Absorption-based clinical computed tomography (CT) is the current imaging method of choice in the diagnosis of lung diseases. Many pulmonary diseases are affecting microscopic structures of the lung, such as terminal bronchi, alveolar spaces, sublobular blood vessels or the pulmonary interstitial tissue. As spatial resolution in CT is limited by the clinically acceptable applied X-ray dose, a comprehensive diagnosis of conditions such as interstitial lung disease, idiopathic pulmonary fibrosis or the characterization of small pulmonary nodules is limited and may require additional validation by invasive lung biopsies. Propagation-based imaging (PBI) is a phase sensitive X-ray imaging technique capable of reaching high spatial resolutions at relatively low applied radiation dose levels. In this publication, we present technical refinements of PBI for the characterization of different artificial lung pathologies, mimicking clinically relevant patterns in ventilated fresh porcine lungs in a human-scale chest phantom. The combination of a very large propagation distance of 10.7 m and a photon counting detector with [Formula: see text] pixel size enabled high resolution PBI CT with significantly improved dose efficiency, measured by thermoluminescence detectors. Image quality was directly compared with state-of-the-art clinical CT. PBI with increased propagation distance was found to provide improved image quality at the same or even lower X-ray dose levels than clinical CT. By combining PBI with iodine k-edge subtraction imaging we further demonstrate that, the high quality of the calculated iodine concentration maps might be a potential tool for the analysis of lung perfusion in great detail. Our results indicate PBI to be of great value for accurate diagnosis of lung disease in patients as it allows to depict pathological lesions non-invasively at high resolution in 3D. This will especially benefit patients at high risk of complications from invasive lung biopsies such as in the setting of suspected idiopathic pulmonary fibrosis (IPF). |
format | Online Article Text |
id | pubmed-10036329 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-100363292023-03-25 High resolution propagation-based lung imaging at clinically relevant X-ray dose levels Albers, Jonas Wagner, Willi L. Fiedler, Mascha O. Rothermel, Anne Wünnemann, Felix Di Lillo, Francesca Dreossi, Diego Sodini, Nicola Baratella, Elisa Confalonieri, Marco Arfelli, Fulvia Kalenka, Armin Lotz, Joachim Biederer, Jürgen Wielpütz, Mark O. Kauczor, Hans-Ulrich Alves, Frauke Tromba, Giuliana Dullin, Christian Sci Rep Article Absorption-based clinical computed tomography (CT) is the current imaging method of choice in the diagnosis of lung diseases. Many pulmonary diseases are affecting microscopic structures of the lung, such as terminal bronchi, alveolar spaces, sublobular blood vessels or the pulmonary interstitial tissue. As spatial resolution in CT is limited by the clinically acceptable applied X-ray dose, a comprehensive diagnosis of conditions such as interstitial lung disease, idiopathic pulmonary fibrosis or the characterization of small pulmonary nodules is limited and may require additional validation by invasive lung biopsies. Propagation-based imaging (PBI) is a phase sensitive X-ray imaging technique capable of reaching high spatial resolutions at relatively low applied radiation dose levels. In this publication, we present technical refinements of PBI for the characterization of different artificial lung pathologies, mimicking clinically relevant patterns in ventilated fresh porcine lungs in a human-scale chest phantom. The combination of a very large propagation distance of 10.7 m and a photon counting detector with [Formula: see text] pixel size enabled high resolution PBI CT with significantly improved dose efficiency, measured by thermoluminescence detectors. Image quality was directly compared with state-of-the-art clinical CT. PBI with increased propagation distance was found to provide improved image quality at the same or even lower X-ray dose levels than clinical CT. By combining PBI with iodine k-edge subtraction imaging we further demonstrate that, the high quality of the calculated iodine concentration maps might be a potential tool for the analysis of lung perfusion in great detail. Our results indicate PBI to be of great value for accurate diagnosis of lung disease in patients as it allows to depict pathological lesions non-invasively at high resolution in 3D. This will especially benefit patients at high risk of complications from invasive lung biopsies such as in the setting of suspected idiopathic pulmonary fibrosis (IPF). Nature Publishing Group UK 2023-03-23 /pmc/articles/PMC10036329/ /pubmed/36959233 http://dx.doi.org/10.1038/s41598-023-30870-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Albers, Jonas Wagner, Willi L. Fiedler, Mascha O. Rothermel, Anne Wünnemann, Felix Di Lillo, Francesca Dreossi, Diego Sodini, Nicola Baratella, Elisa Confalonieri, Marco Arfelli, Fulvia Kalenka, Armin Lotz, Joachim Biederer, Jürgen Wielpütz, Mark O. Kauczor, Hans-Ulrich Alves, Frauke Tromba, Giuliana Dullin, Christian High resolution propagation-based lung imaging at clinically relevant X-ray dose levels |
title | High resolution propagation-based lung imaging at clinically relevant X-ray dose levels |
title_full | High resolution propagation-based lung imaging at clinically relevant X-ray dose levels |
title_fullStr | High resolution propagation-based lung imaging at clinically relevant X-ray dose levels |
title_full_unstemmed | High resolution propagation-based lung imaging at clinically relevant X-ray dose levels |
title_short | High resolution propagation-based lung imaging at clinically relevant X-ray dose levels |
title_sort | high resolution propagation-based lung imaging at clinically relevant x-ray dose levels |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036329/ https://www.ncbi.nlm.nih.gov/pubmed/36959233 http://dx.doi.org/10.1038/s41598-023-30870-y |
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