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Experimental mouse models for translational human cancer research
The development and growth of tumors remains an important and ongoing threat to human life around the world. While advanced therapeutic strategies such as immune checkpoint therapy and CAR-T have achieved astonishing progress in the treatment of both solid and hematological malignancies, the maligna...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036357/ https://www.ncbi.nlm.nih.gov/pubmed/36969176 http://dx.doi.org/10.3389/fimmu.2023.1095388 |
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author | Zhou, Yinxi Xia, Jinghua Xu, Shuonan She, Tao Zhang, Yanning Sun, Ying Wen, Miaomiao Jiang, Tao Xiong, Yanlu Lei, Jie |
author_facet | Zhou, Yinxi Xia, Jinghua Xu, Shuonan She, Tao Zhang, Yanning Sun, Ying Wen, Miaomiao Jiang, Tao Xiong, Yanlu Lei, Jie |
author_sort | Zhou, Yinxi |
collection | PubMed |
description | The development and growth of tumors remains an important and ongoing threat to human life around the world. While advanced therapeutic strategies such as immune checkpoint therapy and CAR-T have achieved astonishing progress in the treatment of both solid and hematological malignancies, the malignant initiation and progression of cancer remains a controversial issue, and further research is urgently required. The experimental animal model not only has great advantages in simulating the occurrence, development, and malignant transformation mechanisms of tumors, but also can be used to evaluate the therapeutic effects of a diverse array of clinical interventions, gradually becoming an indispensable method for cancer research. In this paper, we have reviewed recent research progress in relation to mouse and rat models, focusing on spontaneous, induced, transgenic, and transplantable tumor models, to help guide the future study of malignant mechanisms and tumor prevention. |
format | Online Article Text |
id | pubmed-10036357 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100363572023-03-25 Experimental mouse models for translational human cancer research Zhou, Yinxi Xia, Jinghua Xu, Shuonan She, Tao Zhang, Yanning Sun, Ying Wen, Miaomiao Jiang, Tao Xiong, Yanlu Lei, Jie Front Immunol Immunology The development and growth of tumors remains an important and ongoing threat to human life around the world. While advanced therapeutic strategies such as immune checkpoint therapy and CAR-T have achieved astonishing progress in the treatment of both solid and hematological malignancies, the malignant initiation and progression of cancer remains a controversial issue, and further research is urgently required. The experimental animal model not only has great advantages in simulating the occurrence, development, and malignant transformation mechanisms of tumors, but also can be used to evaluate the therapeutic effects of a diverse array of clinical interventions, gradually becoming an indispensable method for cancer research. In this paper, we have reviewed recent research progress in relation to mouse and rat models, focusing on spontaneous, induced, transgenic, and transplantable tumor models, to help guide the future study of malignant mechanisms and tumor prevention. Frontiers Media S.A. 2023-03-10 /pmc/articles/PMC10036357/ /pubmed/36969176 http://dx.doi.org/10.3389/fimmu.2023.1095388 Text en Copyright © 2023 Zhou, Xia, Xu, She, Zhang, Sun, Wen, Jiang, Xiong and Lei https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Zhou, Yinxi Xia, Jinghua Xu, Shuonan She, Tao Zhang, Yanning Sun, Ying Wen, Miaomiao Jiang, Tao Xiong, Yanlu Lei, Jie Experimental mouse models for translational human cancer research |
title | Experimental mouse models for translational human cancer research |
title_full | Experimental mouse models for translational human cancer research |
title_fullStr | Experimental mouse models for translational human cancer research |
title_full_unstemmed | Experimental mouse models for translational human cancer research |
title_short | Experimental mouse models for translational human cancer research |
title_sort | experimental mouse models for translational human cancer research |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036357/ https://www.ncbi.nlm.nih.gov/pubmed/36969176 http://dx.doi.org/10.3389/fimmu.2023.1095388 |
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