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Tracking auditory mismatch negativity responses during full conscious state and coma

The mismatch negativity (MMN) is considered the electrophysiological change-detection response of the brain, and therefore a valuable clinical tool for monitoring functional changes associated with return to consciousness after severe brain injury. Using an auditory multi-deviant oddball paradigm, w...

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Autores principales: Herrera-Diaz, Adianes, Boshra, Rober, Tavakoli, Paniz, Lin, Chia-Yu A., Pajankar, Netri, Bagheri, Elham, Kolesar, Richard, Fox-Robichaud, Alison, Hamielec, Cindy, Reilly, James P., Connolly, John F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036371/
https://www.ncbi.nlm.nih.gov/pubmed/36970526
http://dx.doi.org/10.3389/fneur.2023.1111691
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author Herrera-Diaz, Adianes
Boshra, Rober
Tavakoli, Paniz
Lin, Chia-Yu A.
Pajankar, Netri
Bagheri, Elham
Kolesar, Richard
Fox-Robichaud, Alison
Hamielec, Cindy
Reilly, James P.
Connolly, John F.
author_facet Herrera-Diaz, Adianes
Boshra, Rober
Tavakoli, Paniz
Lin, Chia-Yu A.
Pajankar, Netri
Bagheri, Elham
Kolesar, Richard
Fox-Robichaud, Alison
Hamielec, Cindy
Reilly, James P.
Connolly, John F.
author_sort Herrera-Diaz, Adianes
collection PubMed
description The mismatch negativity (MMN) is considered the electrophysiological change-detection response of the brain, and therefore a valuable clinical tool for monitoring functional changes associated with return to consciousness after severe brain injury. Using an auditory multi-deviant oddball paradigm, we tracked auditory MMN responses in seventeen healthy controls over a 12-h period, and in three comatose patients assessed over 24 h at two time points. We investigated whether the MMN responses show fluctuations in detectability over time in full conscious awareness, or whether such fluctuations are rather a feature of coma. Three methods of analysis were utilized to determine whether the MMN and subsequent event-related potential (ERP) components could be identified: traditional visual analysis, permutation t-test, and Bayesian analysis. The results showed that the MMN responses elicited to the duration deviant-stimuli are elicited and reliably detected over the course of several hours in healthy controls, at both group and single-subject levels. Preliminary findings in three comatose patients provide further evidence that the MMN is often present in coma, varying within a single patient from easily detectable to undetectable at different times. This highlights the fact that regular and repeated assessments are extremely important when using MMN as a neurophysiological predictor of coma emergence.
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spelling pubmed-100363712023-03-25 Tracking auditory mismatch negativity responses during full conscious state and coma Herrera-Diaz, Adianes Boshra, Rober Tavakoli, Paniz Lin, Chia-Yu A. Pajankar, Netri Bagheri, Elham Kolesar, Richard Fox-Robichaud, Alison Hamielec, Cindy Reilly, James P. Connolly, John F. Front Neurol Neurology The mismatch negativity (MMN) is considered the electrophysiological change-detection response of the brain, and therefore a valuable clinical tool for monitoring functional changes associated with return to consciousness after severe brain injury. Using an auditory multi-deviant oddball paradigm, we tracked auditory MMN responses in seventeen healthy controls over a 12-h period, and in three comatose patients assessed over 24 h at two time points. We investigated whether the MMN responses show fluctuations in detectability over time in full conscious awareness, or whether such fluctuations are rather a feature of coma. Three methods of analysis were utilized to determine whether the MMN and subsequent event-related potential (ERP) components could be identified: traditional visual analysis, permutation t-test, and Bayesian analysis. The results showed that the MMN responses elicited to the duration deviant-stimuli are elicited and reliably detected over the course of several hours in healthy controls, at both group and single-subject levels. Preliminary findings in three comatose patients provide further evidence that the MMN is often present in coma, varying within a single patient from easily detectable to undetectable at different times. This highlights the fact that regular and repeated assessments are extremely important when using MMN as a neurophysiological predictor of coma emergence. Frontiers Media S.A. 2023-03-10 /pmc/articles/PMC10036371/ /pubmed/36970526 http://dx.doi.org/10.3389/fneur.2023.1111691 Text en Copyright © 2023 Herrera-Diaz, Boshra, Tavakoli, Lin, Pajankar, Bagheri, Kolesar, Fox-Robichaud, Hamielec, Reilly and Connolly. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Herrera-Diaz, Adianes
Boshra, Rober
Tavakoli, Paniz
Lin, Chia-Yu A.
Pajankar, Netri
Bagheri, Elham
Kolesar, Richard
Fox-Robichaud, Alison
Hamielec, Cindy
Reilly, James P.
Connolly, John F.
Tracking auditory mismatch negativity responses during full conscious state and coma
title Tracking auditory mismatch negativity responses during full conscious state and coma
title_full Tracking auditory mismatch negativity responses during full conscious state and coma
title_fullStr Tracking auditory mismatch negativity responses during full conscious state and coma
title_full_unstemmed Tracking auditory mismatch negativity responses during full conscious state and coma
title_short Tracking auditory mismatch negativity responses during full conscious state and coma
title_sort tracking auditory mismatch negativity responses during full conscious state and coma
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036371/
https://www.ncbi.nlm.nih.gov/pubmed/36970526
http://dx.doi.org/10.3389/fneur.2023.1111691
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