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The multifaceted biology of lncR-Meg3 in cardio-cerebrovascular diseases

Cardio-cerebrovascular disease, related to high mortality and morbidity worldwide, is a type of cardiovascular or cerebrovascular dysfunction involved in various processes. Therefore, it is imperative to conduct additional research into the pathogenesis and new therapeutic targets of cardiovascular...

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Autores principales: Li, Jing, Liu, Wenxiu, Peng, Fu, Cao, Xiaoyu, Xie, Xiaofang, Peng, Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036404/
https://www.ncbi.nlm.nih.gov/pubmed/36968595
http://dx.doi.org/10.3389/fgene.2023.1132884
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author Li, Jing
Liu, Wenxiu
Peng, Fu
Cao, Xiaoyu
Xie, Xiaofang
Peng, Cheng
author_facet Li, Jing
Liu, Wenxiu
Peng, Fu
Cao, Xiaoyu
Xie, Xiaofang
Peng, Cheng
author_sort Li, Jing
collection PubMed
description Cardio-cerebrovascular disease, related to high mortality and morbidity worldwide, is a type of cardiovascular or cerebrovascular dysfunction involved in various processes. Therefore, it is imperative to conduct additional research into the pathogenesis and new therapeutic targets of cardiovascular and cerebrovascular disorders. Long non-coding RNAs (lncRNAs) have multiple functions and are involved in nearly all cellular biological processes, including translation, transcription, signal transduction, and cell cycle control. LncR-Meg3 is one of them and is becoming increasingly popular. By binding proteins or directly or competitively binding miRNAs, LncR-Meg3 is involved in apoptosis, inflammation, oxidative stress, endoplasmic reticulum stress, epithelial-mesenchymal transition, and other processes. Recent research has shown that LncR-Meg3 is associated with acute myocardial infarction and can be used to diagnose this condition. This article examines the current state of knowledge regarding the expression and regulatory function of LncR-Meg3 in relation to cardiovascular and cerebrovascular diseases. The abnormal expression of LncR-Meg3 can influence neuronal cell death, inflammation, apoptosis, smooth muscle cell proliferation, etc., thereby aggravating or promoting the disease. In addition, we review the bioactive components that target lncR-Meg3 and propose some potential delivery vectors. A comprehensive and in-depth analysis of LncR-Meg3’s role in cardiovascular disease suggests that targeting LncR-Meg3 may be an alternative therapy in the near future, providing new options for slowing the progression of cardiovascular disease.
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spelling pubmed-100364042023-03-25 The multifaceted biology of lncR-Meg3 in cardio-cerebrovascular diseases Li, Jing Liu, Wenxiu Peng, Fu Cao, Xiaoyu Xie, Xiaofang Peng, Cheng Front Genet Genetics Cardio-cerebrovascular disease, related to high mortality and morbidity worldwide, is a type of cardiovascular or cerebrovascular dysfunction involved in various processes. Therefore, it is imperative to conduct additional research into the pathogenesis and new therapeutic targets of cardiovascular and cerebrovascular disorders. Long non-coding RNAs (lncRNAs) have multiple functions and are involved in nearly all cellular biological processes, including translation, transcription, signal transduction, and cell cycle control. LncR-Meg3 is one of them and is becoming increasingly popular. By binding proteins or directly or competitively binding miRNAs, LncR-Meg3 is involved in apoptosis, inflammation, oxidative stress, endoplasmic reticulum stress, epithelial-mesenchymal transition, and other processes. Recent research has shown that LncR-Meg3 is associated with acute myocardial infarction and can be used to diagnose this condition. This article examines the current state of knowledge regarding the expression and regulatory function of LncR-Meg3 in relation to cardiovascular and cerebrovascular diseases. The abnormal expression of LncR-Meg3 can influence neuronal cell death, inflammation, apoptosis, smooth muscle cell proliferation, etc., thereby aggravating or promoting the disease. In addition, we review the bioactive components that target lncR-Meg3 and propose some potential delivery vectors. A comprehensive and in-depth analysis of LncR-Meg3’s role in cardiovascular disease suggests that targeting LncR-Meg3 may be an alternative therapy in the near future, providing new options for slowing the progression of cardiovascular disease. Frontiers Media S.A. 2023-03-10 /pmc/articles/PMC10036404/ /pubmed/36968595 http://dx.doi.org/10.3389/fgene.2023.1132884 Text en Copyright © 2023 Li, Liu, Peng, Cao, Xie and Peng. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Li, Jing
Liu, Wenxiu
Peng, Fu
Cao, Xiaoyu
Xie, Xiaofang
Peng, Cheng
The multifaceted biology of lncR-Meg3 in cardio-cerebrovascular diseases
title The multifaceted biology of lncR-Meg3 in cardio-cerebrovascular diseases
title_full The multifaceted biology of lncR-Meg3 in cardio-cerebrovascular diseases
title_fullStr The multifaceted biology of lncR-Meg3 in cardio-cerebrovascular diseases
title_full_unstemmed The multifaceted biology of lncR-Meg3 in cardio-cerebrovascular diseases
title_short The multifaceted biology of lncR-Meg3 in cardio-cerebrovascular diseases
title_sort multifaceted biology of lncr-meg3 in cardio-cerebrovascular diseases
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036404/
https://www.ncbi.nlm.nih.gov/pubmed/36968595
http://dx.doi.org/10.3389/fgene.2023.1132884
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