Simultaneous targeting of mitochondrial Kv1.3 and lysosomal acid sphingomyelinase amplifies killing of pancreatic ductal adenocarcinoma cells in vitro and in vivo

ABSTRACT: Pancreas ductal adenocarcinoma (PDAC) remains a malignant tumor with very poor prognosis and low 5-year overall survival. Here, we aimed to simultaneously target mitochondria and lysosomes as a new treatment paradigm of malignant pancreas cancer in vitro and in vivo. We demonstrate that th...

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Detalles Bibliográficos
Autores principales: Patel, Sameer H., Bachmann, Magdalena, Kadow, Stephanie, Wilson, Gregory C., Abdel-Salam, Mostafa M. L., Xu, Kui, Keitsch, Simone, Soddemann, Matthias, Wilker, Barbara, Becker, Katrin Anne, Carpinteiro, Alexander, Ahmad, Syed A., Szabo, Ildiko, Gulbins, Erich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036429/
https://www.ncbi.nlm.nih.gov/pubmed/36790532
http://dx.doi.org/10.1007/s00109-023-02290-y

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