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Membrane-camouflaged biomimetic nanoparticles as potential immunomodulatory solutions for sepsis: An overview
Sepsis is a life-threatening organ dysfunction due to dysregulated host responses induced by infection. The presence of immune disturbance is key to the onset and development of sepsis but has remarkably limited therapeutic options. Advances in biomedical nanotechnology have provided innovative appr...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036601/ https://www.ncbi.nlm.nih.gov/pubmed/36970623 http://dx.doi.org/10.3389/fbioe.2023.1111963 |
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author | Wang, Yanbei Liu, Liping Zheng, Xinchuan Liu, Xin |
author_facet | Wang, Yanbei Liu, Liping Zheng, Xinchuan Liu, Xin |
author_sort | Wang, Yanbei |
collection | PubMed |
description | Sepsis is a life-threatening organ dysfunction due to dysregulated host responses induced by infection. The presence of immune disturbance is key to the onset and development of sepsis but has remarkably limited therapeutic options. Advances in biomedical nanotechnology have provided innovative approaches to rebalancing the host immunity. In particular, the technique of membrane-coating has demonstrated remarkable improvements to therapeutic nanoparticles (NPs) in terms of tolerance and stability while also improving their biomimetic performance for immunomodulatory purposes. This development has led to the emergence of using cell-membrane-based biomimetic NPs in treating sepsis-associated immunologic derangements. In this minireview, we present an overview of the recent advances in membrane-camouflaged biomimetic NPs, highlighting their multifaceted immunomodulatory effects in sepsis such as anti-infection, vaccination, inflammation control, reversing of immunosuppression, and targeted delivery of immunomodulatory agents. |
format | Online Article Text |
id | pubmed-10036601 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100366012023-03-25 Membrane-camouflaged biomimetic nanoparticles as potential immunomodulatory solutions for sepsis: An overview Wang, Yanbei Liu, Liping Zheng, Xinchuan Liu, Xin Front Bioeng Biotechnol Bioengineering and Biotechnology Sepsis is a life-threatening organ dysfunction due to dysregulated host responses induced by infection. The presence of immune disturbance is key to the onset and development of sepsis but has remarkably limited therapeutic options. Advances in biomedical nanotechnology have provided innovative approaches to rebalancing the host immunity. In particular, the technique of membrane-coating has demonstrated remarkable improvements to therapeutic nanoparticles (NPs) in terms of tolerance and stability while also improving their biomimetic performance for immunomodulatory purposes. This development has led to the emergence of using cell-membrane-based biomimetic NPs in treating sepsis-associated immunologic derangements. In this minireview, we present an overview of the recent advances in membrane-camouflaged biomimetic NPs, highlighting their multifaceted immunomodulatory effects in sepsis such as anti-infection, vaccination, inflammation control, reversing of immunosuppression, and targeted delivery of immunomodulatory agents. Frontiers Media S.A. 2023-03-10 /pmc/articles/PMC10036601/ /pubmed/36970623 http://dx.doi.org/10.3389/fbioe.2023.1111963 Text en Copyright © 2023 Wang, Liu, Zheng and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Bioengineering and Biotechnology Wang, Yanbei Liu, Liping Zheng, Xinchuan Liu, Xin Membrane-camouflaged biomimetic nanoparticles as potential immunomodulatory solutions for sepsis: An overview |
title | Membrane-camouflaged biomimetic nanoparticles as potential immunomodulatory solutions for sepsis: An overview |
title_full | Membrane-camouflaged biomimetic nanoparticles as potential immunomodulatory solutions for sepsis: An overview |
title_fullStr | Membrane-camouflaged biomimetic nanoparticles as potential immunomodulatory solutions for sepsis: An overview |
title_full_unstemmed | Membrane-camouflaged biomimetic nanoparticles as potential immunomodulatory solutions for sepsis: An overview |
title_short | Membrane-camouflaged biomimetic nanoparticles as potential immunomodulatory solutions for sepsis: An overview |
title_sort | membrane-camouflaged biomimetic nanoparticles as potential immunomodulatory solutions for sepsis: an overview |
topic | Bioengineering and Biotechnology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036601/ https://www.ncbi.nlm.nih.gov/pubmed/36970623 http://dx.doi.org/10.3389/fbioe.2023.1111963 |
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