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Adenosine and P1 receptors: Key targets in the regulation of sleep, torpor, and hibernation
Sleep, torpor, and hibernation are three distinct hypometabolic states. However, they have some similar physiological features, such as decreased core body temperature and slowing heart rate. In addition, the accumulation of adenosine seems to be a common feature before entry into these three states...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036772/ https://www.ncbi.nlm.nih.gov/pubmed/36969831 http://dx.doi.org/10.3389/fphar.2023.1098976 |
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author | Ma, Wei-Xiang Yuan, Ping-Chuan Zhang, Hui Kong, Ling-Xi Lazarus, Michael Qu, Wei-Min Wang, Yi-Qun Huang, Zhi-Li |
author_facet | Ma, Wei-Xiang Yuan, Ping-Chuan Zhang, Hui Kong, Ling-Xi Lazarus, Michael Qu, Wei-Min Wang, Yi-Qun Huang, Zhi-Li |
author_sort | Ma, Wei-Xiang |
collection | PubMed |
description | Sleep, torpor, and hibernation are three distinct hypometabolic states. However, they have some similar physiological features, such as decreased core body temperature and slowing heart rate. In addition, the accumulation of adenosine seems to be a common feature before entry into these three states, suggesting that adenosine and its receptors, also known as P1 receptors, may mediate the initiation and maintenance of these states. This review, therefore, summarizes the current research on the roles and possible neurobiological mechanisms of adenosine and P1 receptors in sleep, torpor, and hibernation. Understanding these aspects will give us better prospects in sleep disorders, therapeutic hypothermia, and aerospace medicine. |
format | Online Article Text |
id | pubmed-10036772 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100367722023-03-25 Adenosine and P1 receptors: Key targets in the regulation of sleep, torpor, and hibernation Ma, Wei-Xiang Yuan, Ping-Chuan Zhang, Hui Kong, Ling-Xi Lazarus, Michael Qu, Wei-Min Wang, Yi-Qun Huang, Zhi-Li Front Pharmacol Pharmacology Sleep, torpor, and hibernation are three distinct hypometabolic states. However, they have some similar physiological features, such as decreased core body temperature and slowing heart rate. In addition, the accumulation of adenosine seems to be a common feature before entry into these three states, suggesting that adenosine and its receptors, also known as P1 receptors, may mediate the initiation and maintenance of these states. This review, therefore, summarizes the current research on the roles and possible neurobiological mechanisms of adenosine and P1 receptors in sleep, torpor, and hibernation. Understanding these aspects will give us better prospects in sleep disorders, therapeutic hypothermia, and aerospace medicine. Frontiers Media S.A. 2023-03-10 /pmc/articles/PMC10036772/ /pubmed/36969831 http://dx.doi.org/10.3389/fphar.2023.1098976 Text en Copyright © 2023 Ma, Yuan, Zhang, Kong, Lazarus, Qu, Wang and Huang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Ma, Wei-Xiang Yuan, Ping-Chuan Zhang, Hui Kong, Ling-Xi Lazarus, Michael Qu, Wei-Min Wang, Yi-Qun Huang, Zhi-Li Adenosine and P1 receptors: Key targets in the regulation of sleep, torpor, and hibernation |
title | Adenosine and P1 receptors: Key targets in the regulation of sleep, torpor, and hibernation |
title_full | Adenosine and P1 receptors: Key targets in the regulation of sleep, torpor, and hibernation |
title_fullStr | Adenosine and P1 receptors: Key targets in the regulation of sleep, torpor, and hibernation |
title_full_unstemmed | Adenosine and P1 receptors: Key targets in the regulation of sleep, torpor, and hibernation |
title_short | Adenosine and P1 receptors: Key targets in the regulation of sleep, torpor, and hibernation |
title_sort | adenosine and p1 receptors: key targets in the regulation of sleep, torpor, and hibernation |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036772/ https://www.ncbi.nlm.nih.gov/pubmed/36969831 http://dx.doi.org/10.3389/fphar.2023.1098976 |
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