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Nlrp12 deficiency alters gut microbiota and ameliorates Fas(lpr) -mediated systemic autoimmunity in male mice

NLRP12 has dual roles in shaping inflammation. We hypothesized that NLRP12 would modulate myeloid cells and T cell function to control systemic autoimmunity. Contrary to our hypothesis, the deficiency of Nlrp12 in autoimmune-prone B6.Fas(lpr/lpr) mice ameliorated autoimmunity in males but not female...

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Detalles Bibliográficos
Autores principales:	Abdelhamid, Leila, Mao, Jiangdi, Cabana-Puig, Xavier, Zhu, Jing, Swartwout, Brianna K., Edwards, Michael R., Testerman, James C., Michaelis, Jacquelyn S., Allen, Irving Coy, Ahmed, S. Ansar, Luo, Xin M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036793/ https://www.ncbi.nlm.nih.gov/pubmed/36969209 http://dx.doi.org/10.3389/fimmu.2023.1120958

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