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Prime editing in hematopoietic stem cells—From ex vivo to in vivo CRISPR-based treatment of blood disorders

Prime editing of human hematopoietic stem cells has the potential to become a safe and efficient way of treating diseases of the blood directly in patients. By allowing site-targeted gene intervention without homology-directed repair donor templates and DNA double-stranded breaks, the invention of p...

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Detalles Bibliográficos
Autores principales:	Wolff, Jonas Holst, Mikkelsen, Jacob Giehm
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Genome Editing
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036844/ https://www.ncbi.nlm.nih.gov/pubmed/36969373 http://dx.doi.org/10.3389/fgeed.2023.1148650

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