Generation of 3D ex vivo mouse- and patient-derived glioma explant slice model for integration of confocal time-lapse imaging and spatial analysis

Development of spatial-integrative pre-clinical models is needed for glioblastoma, which are heterogenous tumors with poor prognosis. Here, we present an optimized protocol to generate three-dimensional ex vivo explant slice glioma model from orthotopic tumors, genetically engineered mouse models, a...

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Detalles Bibliográficos
Autores principales: Comba, Andrea, Varela, Maria Luisa, Faisal, Syed M., Abel, Clifford C., Argento, Anna E., Al-Holou, Wajd N., Hollon, Todd C., Perelman, Jacqueline D., Dunn, Patrick J., Motsch, Sebastien, Castro, Maria G., Lowenstein, Pedro R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036861/
https://www.ncbi.nlm.nih.gov/pubmed/36930648
http://dx.doi.org/10.1016/j.xpro.2023.102174

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