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Mayo Adhesive Probability Score Does Not Have Prognostic Ability in Locally Advanced Renal Cell Carcinoma

Nephrectomy remains standard treatment for renal cell carcinoma (RCC). The Mayo Adhesive Probability (MAP) score is predictive of adherent perinephric fat and associated surgical complexity, and is determined by assessing perinephric fat and stranding. MAP has additionally predicted progression-free...

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Autores principales: Schmeusser, Benjamin N., Manalo, Tad A., Liu, Yuan, Shah, Yash B., Ali, Adil, Armas-Phan, Manuel, Patil, Dattatraya H., Nabavizadeh, Reza, Ogan, Kenneth, Master, Viraj A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Codon Publications 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036918/
https://www.ncbi.nlm.nih.gov/pubmed/36969300
http://dx.doi.org/10.15586/jkcvhl.v10i1.269
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author Schmeusser, Benjamin N.
Manalo, Tad A.
Liu, Yuan
Shah, Yash B.
Ali, Adil
Armas-Phan, Manuel
Patil, Dattatraya H.
Nabavizadeh, Reza
Ogan, Kenneth
Master, Viraj A.
author_facet Schmeusser, Benjamin N.
Manalo, Tad A.
Liu, Yuan
Shah, Yash B.
Ali, Adil
Armas-Phan, Manuel
Patil, Dattatraya H.
Nabavizadeh, Reza
Ogan, Kenneth
Master, Viraj A.
author_sort Schmeusser, Benjamin N.
collection PubMed
description Nephrectomy remains standard treatment for renal cell carcinoma (RCC). The Mayo Adhesive Probability (MAP) score is predictive of adherent perinephric fat and associated surgical complexity, and is determined by assessing perinephric fat and stranding. MAP has additionally predicted progression-free survival (PFS), though primarily reported in stage T1-T2 RCC. Here, we examine MAP’s ability to predict overall survival (OS) and PFS in T3-T4 RCC. From our prospectively maintained RCC database, patients that underwent radical nephrectomy (2009-2016) with available abdominal imaging (<90 days preop) and T3/T4 RCC underwent MAP scoring. Survival analyses were conducted with MAP scores as individual (0-5) and dichotomized (0-3 vs 4-5) using Kaplan-Meier method. Multivariable Cox proportional hazard regression models for PFS and OS were built with backward elimination. 141 patients were included. 134 (95%) and 7 (5%) had pT3 and pT4 disease, respectively. 46.1% of patients had an inferior vena cava thrombus. Mean MAP score was 3.22±1.52, with 75 (53%) patients having a score between 0-3 and 66 (47%) having a score of 4-5. Both male gender (p=0.006) and clear cell histology (p=0.012) were associated with increased MAP scores. On Kaplan-Meier and multivariable analysis, no significant associations were identified between MAP and PFS (HR=1.01, 95% CI 0.85-1.20, p=0.93) or OS (HR=1.01, 95% CI 0.84-1.21, p=0.917). In this cohort of patients with locally advanced RCC, high MAP scores were not predictive of worse PFS or OS.
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spelling pubmed-100369182023-03-25 Mayo Adhesive Probability Score Does Not Have Prognostic Ability in Locally Advanced Renal Cell Carcinoma Schmeusser, Benjamin N. Manalo, Tad A. Liu, Yuan Shah, Yash B. Ali, Adil Armas-Phan, Manuel Patil, Dattatraya H. Nabavizadeh, Reza Ogan, Kenneth Master, Viraj A. J Kidney Cancer VHL Short Communication Nephrectomy remains standard treatment for renal cell carcinoma (RCC). The Mayo Adhesive Probability (MAP) score is predictive of adherent perinephric fat and associated surgical complexity, and is determined by assessing perinephric fat and stranding. MAP has additionally predicted progression-free survival (PFS), though primarily reported in stage T1-T2 RCC. Here, we examine MAP’s ability to predict overall survival (OS) and PFS in T3-T4 RCC. From our prospectively maintained RCC database, patients that underwent radical nephrectomy (2009-2016) with available abdominal imaging (<90 days preop) and T3/T4 RCC underwent MAP scoring. Survival analyses were conducted with MAP scores as individual (0-5) and dichotomized (0-3 vs 4-5) using Kaplan-Meier method. Multivariable Cox proportional hazard regression models for PFS and OS were built with backward elimination. 141 patients were included. 134 (95%) and 7 (5%) had pT3 and pT4 disease, respectively. 46.1% of patients had an inferior vena cava thrombus. Mean MAP score was 3.22±1.52, with 75 (53%) patients having a score between 0-3 and 66 (47%) having a score of 4-5. Both male gender (p=0.006) and clear cell histology (p=0.012) were associated with increased MAP scores. On Kaplan-Meier and multivariable analysis, no significant associations were identified between MAP and PFS (HR=1.01, 95% CI 0.85-1.20, p=0.93) or OS (HR=1.01, 95% CI 0.84-1.21, p=0.917). In this cohort of patients with locally advanced RCC, high MAP scores were not predictive of worse PFS or OS. Codon Publications 2023-03-21 /pmc/articles/PMC10036918/ /pubmed/36969300 http://dx.doi.org/10.15586/jkcvhl.v10i1.269 Text en Copyright: Schmeusser BN, et al. https://creativecommons.org/licenses/by/4.0/License: This open access article is licensed under Creative Commons Attribution 4.0 International (CC BY 4.0). http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/)
spellingShingle Short Communication
Schmeusser, Benjamin N.
Manalo, Tad A.
Liu, Yuan
Shah, Yash B.
Ali, Adil
Armas-Phan, Manuel
Patil, Dattatraya H.
Nabavizadeh, Reza
Ogan, Kenneth
Master, Viraj A.
Mayo Adhesive Probability Score Does Not Have Prognostic Ability in Locally Advanced Renal Cell Carcinoma
title Mayo Adhesive Probability Score Does Not Have Prognostic Ability in Locally Advanced Renal Cell Carcinoma
title_full Mayo Adhesive Probability Score Does Not Have Prognostic Ability in Locally Advanced Renal Cell Carcinoma
title_fullStr Mayo Adhesive Probability Score Does Not Have Prognostic Ability in Locally Advanced Renal Cell Carcinoma
title_full_unstemmed Mayo Adhesive Probability Score Does Not Have Prognostic Ability in Locally Advanced Renal Cell Carcinoma
title_short Mayo Adhesive Probability Score Does Not Have Prognostic Ability in Locally Advanced Renal Cell Carcinoma
title_sort mayo adhesive probability score does not have prognostic ability in locally advanced renal cell carcinoma
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036918/
https://www.ncbi.nlm.nih.gov/pubmed/36969300
http://dx.doi.org/10.15586/jkcvhl.v10i1.269
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