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Increase in distal esophageal wall thickness with time in adult patients with eosinophilic esophagitis

BACKGROUND AND AIM: Eosinophilic esophagitis (EoE) is a chronic disease which may progress to a fibro‐stenotic phenotype due to esophageal sub‐epithelial fibrosis. Esophageal wall thickening in patients with EoE has been demonstrated in a few studies using endoscopic ultrasound (EUS). The aim of thi...

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Autores principales: Wong, Stephanie, Safaeian, Romina, Zobel, Joshua, Holloway, Richard H, Ruszkiewicz, Andrew, Nguyen, Nam Q
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Publishing Asia Pty Ltd 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10037037/
https://www.ncbi.nlm.nih.gov/pubmed/36968573
http://dx.doi.org/10.1002/jgh3.12866
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author Wong, Stephanie
Safaeian, Romina
Zobel, Joshua
Holloway, Richard H
Ruszkiewicz, Andrew
Nguyen, Nam Q
author_facet Wong, Stephanie
Safaeian, Romina
Zobel, Joshua
Holloway, Richard H
Ruszkiewicz, Andrew
Nguyen, Nam Q
author_sort Wong, Stephanie
collection PubMed
description BACKGROUND AND AIM: Eosinophilic esophagitis (EoE) is a chronic disease which may progress to a fibro‐stenotic phenotype due to esophageal sub‐epithelial fibrosis. Esophageal wall thickening in patients with EoE has been demonstrated in a few studies using endoscopic ultrasound (EUS). The aim of this study was to longitudinally assess the endoscopic appearance, wall thickness, histology, and dysphagia score of EoE patients. METHODS: Patients with EoE were recruited and studied between February 2012 and April 2021. Patients were evaluated on two separate occasions at least 12 months apart with endoscopy, EUS, and esophageal mucosal biopsies. The dysphagia score and epidemiology data were also assessed. RESULTS: A total of 16 EoE patients were included with a mean follow‐up duration of 2.2 ± 1.2 years. In 14/16 (88%) patients, the total wall thickness of the distal esophagus significantly increased (P = 0.0012) as a result of thickening of the muscularis propria (P = 0.0218). However, only 1/14 (7%) patient had an increase in the dysphagia score, while 8/14 (57%) and 5/14 (36%) had a stable and reduced dysphagia score, respectively. No differences were found in the total thickness of other esophageal regions, dysphagia score, endoscopic appearance, and eosinophil count over time. CONCLUSION: Distal esophageal wall thickness increases with time in EoE patients, independent of the dysphagia score and eosinophil count.
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spelling pubmed-100370372023-03-25 Increase in distal esophageal wall thickness with time in adult patients with eosinophilic esophagitis Wong, Stephanie Safaeian, Romina Zobel, Joshua Holloway, Richard H Ruszkiewicz, Andrew Nguyen, Nam Q JGH Open Original Articles BACKGROUND AND AIM: Eosinophilic esophagitis (EoE) is a chronic disease which may progress to a fibro‐stenotic phenotype due to esophageal sub‐epithelial fibrosis. Esophageal wall thickening in patients with EoE has been demonstrated in a few studies using endoscopic ultrasound (EUS). The aim of this study was to longitudinally assess the endoscopic appearance, wall thickness, histology, and dysphagia score of EoE patients. METHODS: Patients with EoE were recruited and studied between February 2012 and April 2021. Patients were evaluated on two separate occasions at least 12 months apart with endoscopy, EUS, and esophageal mucosal biopsies. The dysphagia score and epidemiology data were also assessed. RESULTS: A total of 16 EoE patients were included with a mean follow‐up duration of 2.2 ± 1.2 years. In 14/16 (88%) patients, the total wall thickness of the distal esophagus significantly increased (P = 0.0012) as a result of thickening of the muscularis propria (P = 0.0218). However, only 1/14 (7%) patient had an increase in the dysphagia score, while 8/14 (57%) and 5/14 (36%) had a stable and reduced dysphagia score, respectively. No differences were found in the total thickness of other esophageal regions, dysphagia score, endoscopic appearance, and eosinophil count over time. CONCLUSION: Distal esophageal wall thickness increases with time in EoE patients, independent of the dysphagia score and eosinophil count. Wiley Publishing Asia Pty Ltd 2023-02-01 /pmc/articles/PMC10037037/ /pubmed/36968573 http://dx.doi.org/10.1002/jgh3.12866 Text en © 2023 The Authors. JGH Open published by Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Articles
Wong, Stephanie
Safaeian, Romina
Zobel, Joshua
Holloway, Richard H
Ruszkiewicz, Andrew
Nguyen, Nam Q
Increase in distal esophageal wall thickness with time in adult patients with eosinophilic esophagitis
title Increase in distal esophageal wall thickness with time in adult patients with eosinophilic esophagitis
title_full Increase in distal esophageal wall thickness with time in adult patients with eosinophilic esophagitis
title_fullStr Increase in distal esophageal wall thickness with time in adult patients with eosinophilic esophagitis
title_full_unstemmed Increase in distal esophageal wall thickness with time in adult patients with eosinophilic esophagitis
title_short Increase in distal esophageal wall thickness with time in adult patients with eosinophilic esophagitis
title_sort increase in distal esophageal wall thickness with time in adult patients with eosinophilic esophagitis
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10037037/
https://www.ncbi.nlm.nih.gov/pubmed/36968573
http://dx.doi.org/10.1002/jgh3.12866
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