Overexpression of Lmo2 initiates T-lymphoblastic leukemia via impaired thymocyte competition

Cell competition has recently emerged as an important tumor suppressor mechanism in the thymus that inhibits autonomous thymic maintenance. Here, we show that the oncogenic transcription factor Lmo2 causes autonomous thymic maintenance in transgenic mice by inhibiting early T cell differentiation. T...

Descripción completa

Detalles Bibliográficos
Autores principales: Abdulla, Hesham D., Alserihi, Raed, Flensburg, Christoffer, Abeysekera, Waruni, Luo, Meng-Xiao, Gray, Daniel H.D., Liu, Xiaodong, Smyth, Gordon K., Alexander, Warren S., Majewski, Ian J., McCormack, Matthew P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10037042/
https://www.ncbi.nlm.nih.gov/pubmed/36920307
http://dx.doi.org/10.1084/jem.20212383

Ejemplares similares

Ejemplares similares