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Secreted mammalian DNases protect against systemic bacterial infection by digesting biofilms

Extracellular DNase DNASE1L3 maintains tolerance to self-DNA in humans and mice, whereas the role of its homolog DNASE1 remains controversial, and the overall function of secreted DNases in immunity is unclear. We report that deletion of murine DNASE1 neither caused autoreactivity in isolation nor e...

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Detalles Bibliográficos
Autores principales:	Lacey, Keenan A., Serpas, Lee, Makita, Sohei, Wang, Yueyang, Rashidfarrokhi, Ali, Soni, Chetna, Gonzalez, Sandra, Moreira, Andre, Torres, Victor J., Reizis, Boris
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10037111/ https://www.ncbi.nlm.nih.gov/pubmed/36928522 http://dx.doi.org/10.1084/jem.20221086

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