A protocol for the gram-scale synthesis of polyfluoroaryl sulfides via an S(N)Ar step

Polyfluoroaryl sulfide is one of the prevalent motifs ubiquitous in materials and pharmaceutical chemistry. We herein describe a simple yet efficient procedure for their synthesis from readily available thiols and polyfluoroarenes via an S(N)Ar step. We detail specific steps for a gram-scale prepara...

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Detalles Bibliográficos
Autores principales: Chan, Cheng-Lin, Lee, Shao-Chi, Liao, Hsuan-Hung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10037182/
https://www.ncbi.nlm.nih.gov/pubmed/36857078
http://dx.doi.org/10.1016/j.xpro.2023.102043
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author Chan, Cheng-Lin
Lee, Shao-Chi
Liao, Hsuan-Hung
author_facet Chan, Cheng-Lin
Lee, Shao-Chi
Liao, Hsuan-Hung
author_sort Chan, Cheng-Lin
collection PubMed
description Polyfluoroaryl sulfide is one of the prevalent motifs ubiquitous in materials and pharmaceutical chemistry. We herein describe a simple yet efficient procedure for their synthesis from readily available thiols and polyfluoroarenes via an S(N)Ar step. We detail specific steps for a gram-scale preparation of 2-((perfluoropyridin-4-yl)thio)benzo[d]thiazole 3 from mercaptobenzothiazole 1 and pentafluoropyridine 2. For complete details on the use and execution of this protocol, please refer to Liao et al. (2022).(1)
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spelling pubmed-100371822023-03-25 A protocol for the gram-scale synthesis of polyfluoroaryl sulfides via an S(N)Ar step Chan, Cheng-Lin Lee, Shao-Chi Liao, Hsuan-Hung STAR Protoc Protocol Polyfluoroaryl sulfide is one of the prevalent motifs ubiquitous in materials and pharmaceutical chemistry. We herein describe a simple yet efficient procedure for their synthesis from readily available thiols and polyfluoroarenes via an S(N)Ar step. We detail specific steps for a gram-scale preparation of 2-((perfluoropyridin-4-yl)thio)benzo[d]thiazole 3 from mercaptobenzothiazole 1 and pentafluoropyridine 2. For complete details on the use and execution of this protocol, please refer to Liao et al. (2022).(1) Elsevier 2023-01-19 /pmc/articles/PMC10037182/ /pubmed/36857078 http://dx.doi.org/10.1016/j.xpro.2023.102043 Text en © 2023 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Protocol
Chan, Cheng-Lin
Lee, Shao-Chi
Liao, Hsuan-Hung
A protocol for the gram-scale synthesis of polyfluoroaryl sulfides via an S(N)Ar step
title A protocol for the gram-scale synthesis of polyfluoroaryl sulfides via an S(N)Ar step
title_full A protocol for the gram-scale synthesis of polyfluoroaryl sulfides via an S(N)Ar step
title_fullStr A protocol for the gram-scale synthesis of polyfluoroaryl sulfides via an S(N)Ar step
title_full_unstemmed A protocol for the gram-scale synthesis of polyfluoroaryl sulfides via an S(N)Ar step
title_short A protocol for the gram-scale synthesis of polyfluoroaryl sulfides via an S(N)Ar step
title_sort protocol for the gram-scale synthesis of polyfluoroaryl sulfides via an s(n)ar step
topic Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10037182/
https://www.ncbi.nlm.nih.gov/pubmed/36857078
http://dx.doi.org/10.1016/j.xpro.2023.102043
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