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Vaccines against monkeypox

The monkeypox virus is a virus that has 90% genomic homology with the human (smallpox), but it is naturally transmitted between different wild animal reservoirs and is considered a zoonosis. Throughout the 20th century, different vaccines based on the vaccinia poxvirus were developed and used for va...

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Detalles Bibliográficos
Autores principales: Reina, Jordi, Iglesias, Carla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier España, S.L.U. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10037303/
https://www.ncbi.nlm.nih.gov/pubmed/37033199
http://dx.doi.org/10.1016/j.medcle.2023.01.005
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author Reina, Jordi
Iglesias, Carla
author_facet Reina, Jordi
Iglesias, Carla
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description The monkeypox virus is a virus that has 90% genomic homology with the human (smallpox), but it is naturally transmitted between different wild animal reservoirs and is considered a zoonosis. Throughout the 20th century, different vaccines based on the vaccinia poxvirus were developed and used for vaccination against smallpox. After the eradication of smallpox, these vaccines were no longer used. Current vaccines against monkeypox virus are classified by the WHO as replicative (ACAM2000), minimally replicative (LC16m8) and non-replicative (MVA-BN), the latter being the one currently used. The 2022 extra-African monkeypox virus epidemic has highlighted the lack of vaccines with proven efficacy and low reactogenicity. It is considered that the use of this vaccine in the current outbreak may play a role in the prevention or attenuation of the disease as pre-exposure prophylaxis in close contacts of confirmed cases.
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spelling pubmed-100373032023-03-24 Vaccines against monkeypox Reina, Jordi Iglesias, Carla Med Clin (Engl Ed) Review The monkeypox virus is a virus that has 90% genomic homology with the human (smallpox), but it is naturally transmitted between different wild animal reservoirs and is considered a zoonosis. Throughout the 20th century, different vaccines based on the vaccinia poxvirus were developed and used for vaccination against smallpox. After the eradication of smallpox, these vaccines were no longer used. Current vaccines against monkeypox virus are classified by the WHO as replicative (ACAM2000), minimally replicative (LC16m8) and non-replicative (MVA-BN), the latter being the one currently used. The 2022 extra-African monkeypox virus epidemic has highlighted the lack of vaccines with proven efficacy and low reactogenicity. It is considered that the use of this vaccine in the current outbreak may play a role in the prevention or attenuation of the disease as pre-exposure prophylaxis in close contacts of confirmed cases. Elsevier España, S.L.U. 2023-04-06 2023-03-24 /pmc/articles/PMC10037303/ /pubmed/37033199 http://dx.doi.org/10.1016/j.medcle.2023.01.005 Text en © 2023 Elsevier España, S.L.U. All rights reserved. Elsevier has created a Monkeypox Information Center (https://www.elsevier.com/connect/monkeypox-information-center) in response to the declared public health emergency of international concern, with free information in English on the monkeypox virus. The Monkeypox Information Center is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its monkeypox related research that is available on the Monkeypox Information Center - including this research content - immediately available in publicly funded repositories, with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the Monkeypox Information Center remains active.
spellingShingle Review
Reina, Jordi
Iglesias, Carla
Vaccines against monkeypox
title Vaccines against monkeypox
title_full Vaccines against monkeypox
title_fullStr Vaccines against monkeypox
title_full_unstemmed Vaccines against monkeypox
title_short Vaccines against monkeypox
title_sort vaccines against monkeypox
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10037303/
https://www.ncbi.nlm.nih.gov/pubmed/37033199
http://dx.doi.org/10.1016/j.medcle.2023.01.005
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