O-Linked Sialoglycans Modulate the Proteolysis of SARS-CoV-2 Spike and Likely Contribute to the Mutational Trajectory in Variants of Concern

[Image: see text] The emergence of a polybasic cleavage motif for the protease furin in SARS-CoV-2 spike has been established as a major factor for human viral transmission. The region N-terminal to that motif is extensively mutated in variants of concern (VOCs). Besides furin, spikes from these var...

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Detalles Bibliográficos
Autores principales: Gonzalez-Rodriguez, Edgar, Zol-Hanlon, Mia, Bineva-Todd, Ganka, Marchesi, Andrea, Skehel, Mark, Mahoney, Keira E., Roustan, Chloë, Borg, Annabel, Di Vagno, Lucia, Kjær, Svend, Wrobel, Antoni G., Benton, Donald J., Nawrath, Philipp, Flitsch, Sabine L., Joshi, Dhira, González-Ramírez, Andrés Manuel, Wilkinson, Katalin A., Wilkinson, Robert J., Wall, Emma C., Hurtado-Guerrero, Ramón, Malaker, Stacy A., Schumann, Benjamin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10037455/
https://www.ncbi.nlm.nih.gov/pubmed/36968546
http://dx.doi.org/10.1021/acscentsci.2c01349

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