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Quantification and Mapping of Alkylation in the Human Genome Reveal Single Nucleotide Resolution Precursors of Mutational Signatures

[Image: see text] Chemical modifications to DNA bases, including DNA adducts arising from reactions with electrophilic chemicals, are well-known to impact cell growth, miscode during replication, and influence disease etiology. However, knowledge of how genomic sequences and structures influence the...

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Detalles Bibliográficos
Autores principales:	Jiang, Yang, Mingard, Cécile, Huber, Sabrina M., Takhaveev, Vakil, McKeague, Maureen, Kizaki, Seiichiro, Schneider, Mirjam, Ziegler, Nathalie, Hürlimann, Vera, Hoeng, Julia, Sierro, Nicolas, Ivanov, Nikolai V., Sturla, Shana J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10037492/ https://www.ncbi.nlm.nih.gov/pubmed/36968528 http://dx.doi.org/10.1021/acscentsci.2c01100

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