Topoisomerase I Inhibition Radiosensitizing Hepatocellular Carcinoma by RNF144A-mediated DNA-PKcs Ubiquitination and Natural Killer Cell Cytotoxicity

BACKGROUND AND AIMS: Topoisomerase I (TOP1) participates the repair of DNA double-strand breaks (DSBs) upon radiation therapy (RT). RNF144A mediates ubiquitination of catalytic subunit of DNA protein kinase (DNA-PKcs), a critical factor in DSB repair. This study aimed to investigate the natural kill...

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Detalles Bibliográficos
Autores principales: Tsai, Chiao-Ling, Yang, Po-Sheng, Hsu, Feng-Ming, Cheng, Ann-Lii, Yu, Wan-Ni, Cheng, Jason Chia-Hsien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: XIA & HE Publishing Inc. 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10037509/
https://www.ncbi.nlm.nih.gov/pubmed/36969901
http://dx.doi.org/10.14218/JCTH.2022.00271

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10037509/
https://www.ncbi.nlm.nih.gov/pubmed/36969901
http://dx.doi.org/10.14218/JCTH.2022.00271

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