Diurnal Changes in Capecitabine Clock-Controlled Metabolism Enzymes Are Responsible for Its Pharmacokinetics in Male Mice

The circadian timing system controls absorption, distribution, metabolism, and elimination processes of drug pharmacokinetics over a 24-h period. Exposure of target tissues to the active form of the drug and cytotoxicity display variations depending on the chronopharmacokinetics. For anticancer drug...

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Detalles Bibliográficos
Autores principales: Akyel, Yasemin Kubra, Ozturk Civelek, Dilek, Ozturk Seyhan, Narin, Gul, Seref, Gazioglu, Isil, Pala Kara, Zeliha, Lévi, Francis, Kavakli, Ibrahim Halil, Okyar, Alper
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2023
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10037547/
https://www.ncbi.nlm.nih.gov/pubmed/36762608
http://dx.doi.org/10.1177/07487304221148779

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10037547/
https://www.ncbi.nlm.nih.gov/pubmed/36762608
http://dx.doi.org/10.1177/07487304221148779

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