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Treatment with Testosterone Therapy in Type 2 Diabetic Hypogonadal Adult Males: A Systematic Review and Meta-Analysis

Testosterone replacement therapy (TRT) has been used to treat hypogonadal males with type 2 diabetes mellitus (T2DM) for a long time, despite variable results. This meta-analysis examines TRT’s role in hypogonadal males with T2DM. The databases PubMed, Embase, and Google Scholar were searched for re...

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Autores principales: Kumari, Kajol, Kumar, Rohan, Memon, Areeba, Kumari, Beena, Tehrim, Moniba, Kumari, Pooja, Shehryar, Muhammad, Islam, Hamza, Islam, Rabia, Khatri, Mahima, Kumar, Satesh, Kumar, Ajay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10037582/
https://www.ncbi.nlm.nih.gov/pubmed/36961066
http://dx.doi.org/10.3390/clinpract13020041
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author Kumari, Kajol
Kumar, Rohan
Memon, Areeba
Kumari, Beena
Tehrim, Moniba
Kumari, Pooja
Shehryar, Muhammad
Islam, Hamza
Islam, Rabia
Khatri, Mahima
Kumar, Satesh
Kumar, Ajay
author_facet Kumari, Kajol
Kumar, Rohan
Memon, Areeba
Kumari, Beena
Tehrim, Moniba
Kumari, Pooja
Shehryar, Muhammad
Islam, Hamza
Islam, Rabia
Khatri, Mahima
Kumar, Satesh
Kumar, Ajay
author_sort Kumari, Kajol
collection PubMed
description Testosterone replacement therapy (TRT) has been used to treat hypogonadal males with type 2 diabetes mellitus (T2DM) for a long time, despite variable results. This meta-analysis examines TRT’s role in hypogonadal males with T2DM. The databases PubMed, Embase, and Google Scholar were searched for relevant RCTs and observational studies. Estimated pooled mean differences (MDs) and relative risks with 95% confidence intervals were used to measure the effects of TRT (CIs). When compared to the placebo, TRT improves glycemic management by significantly reducing glycated hemoglobin (HBA1c) levels (WMD = −0.29 [−0.57, −0.02] p = 0.04; I2 = 89.8%). Additionally, it reduces the homeostatic model assessment levels of insulin resistance (WMD = −1.47 [−3.14, 0.19]; p = 0.08; I2 = 56.3%), fasting glucose (WMD = −0.30 [−0.75, 0.15]; p = 0.19; I2 = 84.4%), and fasting insulin (WMD = −2.95 [−8.64, 2.74]; however, these results are non-significant. On the other hand, HBA1c levels are significantly reduced with TRT; in addition, total testosterone levels significantly increase with testosterone replacement therapy (WMD = 4.51 [2.40, 6.61] p = 0.0001; I2 = 96.3%). Based on our results, we hypothesize that TRT can improve glycemic control and hormone levels, as well as lower total cholesterol, triglyceride, and LDL cholesterol levels while raising HDL cholesterol in hypogonadal type 2 diabetes patients. To this end, we recommend TRT for these patients in addition to standard diabetes care.
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spelling pubmed-100375822023-03-25 Treatment with Testosterone Therapy in Type 2 Diabetic Hypogonadal Adult Males: A Systematic Review and Meta-Analysis Kumari, Kajol Kumar, Rohan Memon, Areeba Kumari, Beena Tehrim, Moniba Kumari, Pooja Shehryar, Muhammad Islam, Hamza Islam, Rabia Khatri, Mahima Kumar, Satesh Kumar, Ajay Clin Pract Review Testosterone replacement therapy (TRT) has been used to treat hypogonadal males with type 2 diabetes mellitus (T2DM) for a long time, despite variable results. This meta-analysis examines TRT’s role in hypogonadal males with T2DM. The databases PubMed, Embase, and Google Scholar were searched for relevant RCTs and observational studies. Estimated pooled mean differences (MDs) and relative risks with 95% confidence intervals were used to measure the effects of TRT (CIs). When compared to the placebo, TRT improves glycemic management by significantly reducing glycated hemoglobin (HBA1c) levels (WMD = −0.29 [−0.57, −0.02] p = 0.04; I2 = 89.8%). Additionally, it reduces the homeostatic model assessment levels of insulin resistance (WMD = −1.47 [−3.14, 0.19]; p = 0.08; I2 = 56.3%), fasting glucose (WMD = −0.30 [−0.75, 0.15]; p = 0.19; I2 = 84.4%), and fasting insulin (WMD = −2.95 [−8.64, 2.74]; however, these results are non-significant. On the other hand, HBA1c levels are significantly reduced with TRT; in addition, total testosterone levels significantly increase with testosterone replacement therapy (WMD = 4.51 [2.40, 6.61] p = 0.0001; I2 = 96.3%). Based on our results, we hypothesize that TRT can improve glycemic control and hormone levels, as well as lower total cholesterol, triglyceride, and LDL cholesterol levels while raising HDL cholesterol in hypogonadal type 2 diabetes patients. To this end, we recommend TRT for these patients in addition to standard diabetes care. MDPI 2023-03-20 /pmc/articles/PMC10037582/ /pubmed/36961066 http://dx.doi.org/10.3390/clinpract13020041 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kumari, Kajol
Kumar, Rohan
Memon, Areeba
Kumari, Beena
Tehrim, Moniba
Kumari, Pooja
Shehryar, Muhammad
Islam, Hamza
Islam, Rabia
Khatri, Mahima
Kumar, Satesh
Kumar, Ajay
Treatment with Testosterone Therapy in Type 2 Diabetic Hypogonadal Adult Males: A Systematic Review and Meta-Analysis
title Treatment with Testosterone Therapy in Type 2 Diabetic Hypogonadal Adult Males: A Systematic Review and Meta-Analysis
title_full Treatment with Testosterone Therapy in Type 2 Diabetic Hypogonadal Adult Males: A Systematic Review and Meta-Analysis
title_fullStr Treatment with Testosterone Therapy in Type 2 Diabetic Hypogonadal Adult Males: A Systematic Review and Meta-Analysis
title_full_unstemmed Treatment with Testosterone Therapy in Type 2 Diabetic Hypogonadal Adult Males: A Systematic Review and Meta-Analysis
title_short Treatment with Testosterone Therapy in Type 2 Diabetic Hypogonadal Adult Males: A Systematic Review and Meta-Analysis
title_sort treatment with testosterone therapy in type 2 diabetic hypogonadal adult males: a systematic review and meta-analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10037582/
https://www.ncbi.nlm.nih.gov/pubmed/36961066
http://dx.doi.org/10.3390/clinpract13020041
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