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Repeated Lung Ultrasound versus Chest X-ray—Which One Predicts Better Clinical Outcome in COVID-19?

The purpose of this study was to evaluate whether changes in repeated lung ultrasound (LUS) or chest X-ray (CXR) of coronavirus disease 2019 (COVID-19) patients can predict the development of severe disease and the need for treatment in the intensive care unit (ICU). In this prospective monocentric...

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Autores principales: Spogis, Jakob, Fusco, Stefano, Hagen, Florian, Kaufmann, Sascha, Malek, Nisar, Hoffmann, Tatjana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10037641/
https://www.ncbi.nlm.nih.gov/pubmed/36961015
http://dx.doi.org/10.3390/tomography9020056
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author Spogis, Jakob
Fusco, Stefano
Hagen, Florian
Kaufmann, Sascha
Malek, Nisar
Hoffmann, Tatjana
author_facet Spogis, Jakob
Fusco, Stefano
Hagen, Florian
Kaufmann, Sascha
Malek, Nisar
Hoffmann, Tatjana
author_sort Spogis, Jakob
collection PubMed
description The purpose of this study was to evaluate whether changes in repeated lung ultrasound (LUS) or chest X-ray (CXR) of coronavirus disease 2019 (COVID-19) patients can predict the development of severe disease and the need for treatment in the intensive care unit (ICU). In this prospective monocentric study, COVID-19 patients received standardized LUS and CXR at day 1, 3 and 5. Scores for changes in LUS (LUS score) and CXR (RALE and M-RALE) were calculated and compared. Intra-class correlation was calculated for two readers of CXR and ROC analysis to evaluate the best discriminator for the need for ICU treatment. A total of 30 patients were analyzed, 26 patients with follow-up LUS and CXR. Increase in M-RALE between baseline and follow-up 1 was significantly higher in patients with need for ICU treatment in the further hospital stay (p = 0.008). Both RALE and M-RALE significantly correlated with LUS score (r = 0.5, p < 0.0001). ROC curves with need for ICU treatment as separator were not significantly different for changes in M-RALE (AUC: 0.87) and LUS score (AUC: 0.79), both being good discriminators. ICC was moderate for RALE (0.56) and substantial for M-RALE (0.74). The present study demonstrates that both follow-up LUS and CXR are powerful tools to track the evolution of COVID-19, and can be used equally as predictors for the need for ICU treatment.
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spelling pubmed-100376412023-03-25 Repeated Lung Ultrasound versus Chest X-ray—Which One Predicts Better Clinical Outcome in COVID-19? Spogis, Jakob Fusco, Stefano Hagen, Florian Kaufmann, Sascha Malek, Nisar Hoffmann, Tatjana Tomography Article The purpose of this study was to evaluate whether changes in repeated lung ultrasound (LUS) or chest X-ray (CXR) of coronavirus disease 2019 (COVID-19) patients can predict the development of severe disease and the need for treatment in the intensive care unit (ICU). In this prospective monocentric study, COVID-19 patients received standardized LUS and CXR at day 1, 3 and 5. Scores for changes in LUS (LUS score) and CXR (RALE and M-RALE) were calculated and compared. Intra-class correlation was calculated for two readers of CXR and ROC analysis to evaluate the best discriminator for the need for ICU treatment. A total of 30 patients were analyzed, 26 patients with follow-up LUS and CXR. Increase in M-RALE between baseline and follow-up 1 was significantly higher in patients with need for ICU treatment in the further hospital stay (p = 0.008). Both RALE and M-RALE significantly correlated with LUS score (r = 0.5, p < 0.0001). ROC curves with need for ICU treatment as separator were not significantly different for changes in M-RALE (AUC: 0.87) and LUS score (AUC: 0.79), both being good discriminators. ICC was moderate for RALE (0.56) and substantial for M-RALE (0.74). The present study demonstrates that both follow-up LUS and CXR are powerful tools to track the evolution of COVID-19, and can be used equally as predictors for the need for ICU treatment. MDPI 2023-03-21 /pmc/articles/PMC10037641/ /pubmed/36961015 http://dx.doi.org/10.3390/tomography9020056 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Spogis, Jakob
Fusco, Stefano
Hagen, Florian
Kaufmann, Sascha
Malek, Nisar
Hoffmann, Tatjana
Repeated Lung Ultrasound versus Chest X-ray—Which One Predicts Better Clinical Outcome in COVID-19?
title Repeated Lung Ultrasound versus Chest X-ray—Which One Predicts Better Clinical Outcome in COVID-19?
title_full Repeated Lung Ultrasound versus Chest X-ray—Which One Predicts Better Clinical Outcome in COVID-19?
title_fullStr Repeated Lung Ultrasound versus Chest X-ray—Which One Predicts Better Clinical Outcome in COVID-19?
title_full_unstemmed Repeated Lung Ultrasound versus Chest X-ray—Which One Predicts Better Clinical Outcome in COVID-19?
title_short Repeated Lung Ultrasound versus Chest X-ray—Which One Predicts Better Clinical Outcome in COVID-19?
title_sort repeated lung ultrasound versus chest x-ray—which one predicts better clinical outcome in covid-19?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10037641/
https://www.ncbi.nlm.nih.gov/pubmed/36961015
http://dx.doi.org/10.3390/tomography9020056
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