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Receptor tyrosine kinase C-kit promotes a destructive phenotype of FLS in osteoarthritis via intracellular EMT signaling

BACKGROUND: Chronic inflammation, mainly derived from fibroblast-like synoviocytes (FLSs), plays a central role in the pathomechanism of osteoarthritis (OA). Recently, epithelial-mesenchymal transition (EMT) signaling was found to be activated in OA-derived FLSs with a pro-inflammatory phenotype. Ho...

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Detalles Bibliográficos
Autores principales:	Cao, Xu, Wu, Song, Wang, Xinxing, Huang, Junjie, Zhang, Wenxiu, Liang, Chi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10037859/ https://www.ncbi.nlm.nih.gov/pubmed/36959556 http://dx.doi.org/10.1186/s10020-023-00633-6

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