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Association between preoperative neurocognitive status and IDH1 mutation status in high-grade gliomas

BACKGROUND: High-grade glioma (HGG) patients present with variable impairment in neurocognitive function (NCF). Based on that, isocitrate dehydrogenase 1 (IDH1) wild-type HGGs are more aggressive than IDH1 mutant-type ones, we hypothesized that patients with IDH1 wild-type HGG would exhibit more sev...

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Autores principales: Liouta, Evangelia, Kalyvas, Aristotelis V, Komaitis, Spyridon, Drosos, Evangelos, Koutsarnakis, Christos, García-Gómez, Juan M, Juan-Albarracín, Javier, Katsaros, Vasileios, Kalamatianos, Theodosis, Argyrakos, Theodoros, Stranjalis, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10037936/
https://www.ncbi.nlm.nih.gov/pubmed/36970174
http://dx.doi.org/10.1093/nop/npac077
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author Liouta, Evangelia
Kalyvas, Aristotelis V
Komaitis, Spyridon
Drosos, Evangelos
Koutsarnakis, Christos
García-Gómez, Juan M
Juan-Albarracín, Javier
Katsaros, Vasileios
Kalamatianos, Theodosis
Argyrakos, Theodoros
Stranjalis, George
author_facet Liouta, Evangelia
Kalyvas, Aristotelis V
Komaitis, Spyridon
Drosos, Evangelos
Koutsarnakis, Christos
García-Gómez, Juan M
Juan-Albarracín, Javier
Katsaros, Vasileios
Kalamatianos, Theodosis
Argyrakos, Theodoros
Stranjalis, George
author_sort Liouta, Evangelia
collection PubMed
description BACKGROUND: High-grade glioma (HGG) patients present with variable impairment in neurocognitive function (NCF). Based on that, isocitrate dehydrogenase 1 (IDH1) wild-type HGGs are more aggressive than IDH1 mutant-type ones, we hypothesized that patients with IDH1 wild-type HGG would exhibit more severe NCF deficits than their IDH1 mutant counterparts. METHODS: NCF was assessed by Mini Mental Status Exam (MMSE), Trail Making Test (TMT), Digit Span (DS), and Controlled Word Association Test (COWAT) tests in 147 HGG patients preoperatively. RESULTS: Analyses between IDH1 groups revealed a significant difference on MMSE concentration component (p ≤ .01), DS (p ≤ .01), TMTB (p ≤ .01), and COWAT (p ≤ .01) scores, with the IDH1 wild group performing worse than the IDH1 mutant one. Age and tumor volume were inversely correlated with MMSE concentration component (r = −4.78, p < .01), and with MMSE concentration (r = −.401, p < .01), TMTB (r = −.328, p < .01), and COWAT phonemic scores (r = −.599, p < .01), respectively, but only for the IDH1 wild-type group. Analyses between age-matched subsamples of IDH1 groups revealed no age effect on NCF. Tumor grade showed nonsignificance on NCF (p > .05) between the 2 IDH1 mutation subgroups of grade IV tumor patients. On the contrary, grade III group showed a significant difference in TMTB (p < .01) and DS backwards (p < .01) between IDH1 subgroups, with the mutant one outperforming the IDH1 wild one. CONCLUSIONS: Our findings indicate that IDH1 wild-type HGG patients present greater NCF impairment, in executive functions particularly, compared to IDH1 mutant ones, suggesting that tumor growth kinetics may play a more profound role than other tumor and demographic parameters in clinical NCF of HGG patients.
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spelling pubmed-100379362023-03-25 Association between preoperative neurocognitive status and IDH1 mutation status in high-grade gliomas Liouta, Evangelia Kalyvas, Aristotelis V Komaitis, Spyridon Drosos, Evangelos Koutsarnakis, Christos García-Gómez, Juan M Juan-Albarracín, Javier Katsaros, Vasileios Kalamatianos, Theodosis Argyrakos, Theodoros Stranjalis, George Neurooncol Pract Original Articles BACKGROUND: High-grade glioma (HGG) patients present with variable impairment in neurocognitive function (NCF). Based on that, isocitrate dehydrogenase 1 (IDH1) wild-type HGGs are more aggressive than IDH1 mutant-type ones, we hypothesized that patients with IDH1 wild-type HGG would exhibit more severe NCF deficits than their IDH1 mutant counterparts. METHODS: NCF was assessed by Mini Mental Status Exam (MMSE), Trail Making Test (TMT), Digit Span (DS), and Controlled Word Association Test (COWAT) tests in 147 HGG patients preoperatively. RESULTS: Analyses between IDH1 groups revealed a significant difference on MMSE concentration component (p ≤ .01), DS (p ≤ .01), TMTB (p ≤ .01), and COWAT (p ≤ .01) scores, with the IDH1 wild group performing worse than the IDH1 mutant one. Age and tumor volume were inversely correlated with MMSE concentration component (r = −4.78, p < .01), and with MMSE concentration (r = −.401, p < .01), TMTB (r = −.328, p < .01), and COWAT phonemic scores (r = −.599, p < .01), respectively, but only for the IDH1 wild-type group. Analyses between age-matched subsamples of IDH1 groups revealed no age effect on NCF. Tumor grade showed nonsignificance on NCF (p > .05) between the 2 IDH1 mutation subgroups of grade IV tumor patients. On the contrary, grade III group showed a significant difference in TMTB (p < .01) and DS backwards (p < .01) between IDH1 subgroups, with the mutant one outperforming the IDH1 wild one. CONCLUSIONS: Our findings indicate that IDH1 wild-type HGG patients present greater NCF impairment, in executive functions particularly, compared to IDH1 mutant ones, suggesting that tumor growth kinetics may play a more profound role than other tumor and demographic parameters in clinical NCF of HGG patients. Oxford University Press 2022-09-30 /pmc/articles/PMC10037936/ /pubmed/36970174 http://dx.doi.org/10.1093/nop/npac077 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of the Society for Neuro-Oncology and the European Association of Neuro-Oncology. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Liouta, Evangelia
Kalyvas, Aristotelis V
Komaitis, Spyridon
Drosos, Evangelos
Koutsarnakis, Christos
García-Gómez, Juan M
Juan-Albarracín, Javier
Katsaros, Vasileios
Kalamatianos, Theodosis
Argyrakos, Theodoros
Stranjalis, George
Association between preoperative neurocognitive status and IDH1 mutation status in high-grade gliomas
title Association between preoperative neurocognitive status and IDH1 mutation status in high-grade gliomas
title_full Association between preoperative neurocognitive status and IDH1 mutation status in high-grade gliomas
title_fullStr Association between preoperative neurocognitive status and IDH1 mutation status in high-grade gliomas
title_full_unstemmed Association between preoperative neurocognitive status and IDH1 mutation status in high-grade gliomas
title_short Association between preoperative neurocognitive status and IDH1 mutation status in high-grade gliomas
title_sort association between preoperative neurocognitive status and idh1 mutation status in high-grade gliomas
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10037936/
https://www.ncbi.nlm.nih.gov/pubmed/36970174
http://dx.doi.org/10.1093/nop/npac077
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