Vesicle‐Associated Actin Assembly by Formins Promotes TGFβ‐Induced ANGPTL4 Trafficking, Secretion and Cell Invasion (Adv. Sci. 9/2023)

Actin Dynamics In article number 2204896, a novel role of the formin FMNL2 is uncovered by Dennis Frank, Christel Jessica Moussi, Carsten Schwan, Robert Grosse, and co‐workers. TGFβ‐induced processes, such as cell invasion and the secretion and trafficking of the pro‐metastatic factor ANGPTL4 requir...

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Autores principales: Frank, Dennis, Moussi, Christel Jessica, Ulferts, Svenja, Lorenzen, Lina, Schwan, Carsten, Grosse, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Frontispiece
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10037950/
http://dx.doi.org/10.1002/advs.202370052
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author Frank, Dennis
Moussi, Christel Jessica
Ulferts, Svenja
Lorenzen, Lina
Schwan, Carsten
Grosse, Robert
author_facet Frank, Dennis
Moussi, Christel Jessica
Ulferts, Svenja
Lorenzen, Lina
Schwan, Carsten
Grosse, Robert
author_sort Frank, Dennis
collection PubMed
description Actin Dynamics In article number 2204896, a novel role of the formin FMNL2 is uncovered by Dennis Frank, Christel Jessica Moussi, Carsten Schwan, Robert Grosse, and co‐workers. TGFβ‐induced processes, such as cell invasion and the secretion and trafficking of the pro‐metastatic factor ANGPTL4 require phospho‐activated FMNL2. Live cell super‐resolution microscopy allows the observation of FMNL2 directly polymerizing actin at motile ANGPTL4‐containing vesicles. A time course of FMNL2 (green) and actin polymerization (cyan) at an ANGPTL4 vesicle (magenta) is shown, starting from the association of FMNL2 (top left) and ending with the dissociation of the formin (bottom right). [Image: see text]
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spelling pubmed-100379502023-03-25 Vesicle‐Associated Actin Assembly by Formins Promotes TGFβ‐Induced ANGPTL4 Trafficking, Secretion and Cell Invasion (Adv. Sci. 9/2023) Frank, Dennis Moussi, Christel Jessica Ulferts, Svenja Lorenzen, Lina Schwan, Carsten Grosse, Robert Adv Sci (Weinh) Frontispiece Actin Dynamics In article number 2204896, a novel role of the formin FMNL2 is uncovered by Dennis Frank, Christel Jessica Moussi, Carsten Schwan, Robert Grosse, and co‐workers. TGFβ‐induced processes, such as cell invasion and the secretion and trafficking of the pro‐metastatic factor ANGPTL4 require phospho‐activated FMNL2. Live cell super‐resolution microscopy allows the observation of FMNL2 directly polymerizing actin at motile ANGPTL4‐containing vesicles. A time course of FMNL2 (green) and actin polymerization (cyan) at an ANGPTL4 vesicle (magenta) is shown, starting from the association of FMNL2 (top left) and ending with the dissociation of the formin (bottom right). [Image: see text] John Wiley and Sons Inc. 2023-03-24 /pmc/articles/PMC10037950/ http://dx.doi.org/10.1002/advs.202370052 Text en © 2023 Wiley‐VCH GmbH https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Frontispiece
Frank, Dennis
Moussi, Christel Jessica
Ulferts, Svenja
Lorenzen, Lina
Schwan, Carsten
Grosse, Robert
Vesicle‐Associated Actin Assembly by Formins Promotes TGFβ‐Induced ANGPTL4 Trafficking, Secretion and Cell Invasion (Adv. Sci. 9/2023)
title Vesicle‐Associated Actin Assembly by Formins Promotes TGFβ‐Induced ANGPTL4 Trafficking, Secretion and Cell Invasion (Adv. Sci. 9/2023)
title_full Vesicle‐Associated Actin Assembly by Formins Promotes TGFβ‐Induced ANGPTL4 Trafficking, Secretion and Cell Invasion (Adv. Sci. 9/2023)
title_fullStr Vesicle‐Associated Actin Assembly by Formins Promotes TGFβ‐Induced ANGPTL4 Trafficking, Secretion and Cell Invasion (Adv. Sci. 9/2023)
title_full_unstemmed Vesicle‐Associated Actin Assembly by Formins Promotes TGFβ‐Induced ANGPTL4 Trafficking, Secretion and Cell Invasion (Adv. Sci. 9/2023)
title_short Vesicle‐Associated Actin Assembly by Formins Promotes TGFβ‐Induced ANGPTL4 Trafficking, Secretion and Cell Invasion (Adv. Sci. 9/2023)
title_sort vesicle‐associated actin assembly by formins promotes tgfβ‐induced angptl4 trafficking, secretion and cell invasion (adv. sci. 9/2023)
topic Frontispiece
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10037950/
http://dx.doi.org/10.1002/advs.202370052
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