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Fasting: From Physiology to Pathology
Overnutrition is a risk factor for various human diseases, including neurodegenerative diseases, metabolic disorders, and cancers. Therefore, targeting overnutrition represents a simple but attractive strategy for the treatment of these increasing public health threats. Fasting as a dietary interven...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10037992/ https://www.ncbi.nlm.nih.gov/pubmed/36737846 http://dx.doi.org/10.1002/advs.202204487 |
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author | Tang, Dongmei Tang, Qiuyan Huang, Wei Zhang, Yuwei Tian, Yan Fu, Xianghui |
author_facet | Tang, Dongmei Tang, Qiuyan Huang, Wei Zhang, Yuwei Tian, Yan Fu, Xianghui |
author_sort | Tang, Dongmei |
collection | PubMed |
description | Overnutrition is a risk factor for various human diseases, including neurodegenerative diseases, metabolic disorders, and cancers. Therefore, targeting overnutrition represents a simple but attractive strategy for the treatment of these increasing public health threats. Fasting as a dietary intervention for combating overnutrition has been extensively studied. Fasting has been practiced for millennia, but only recently have its roles in the molecular clock, gut microbiome, and tissue homeostasis and function emerged. Fasting can slow aging in most species and protect against various human diseases, including neurodegenerative diseases, metabolic disorders, and cancers. These centuried and unfading adventures and explorations suggest that fasting has the potential to delay aging and help prevent and treat diseases while minimizing side effects caused by chronic dietary interventions. In this review, recent animal and human studies concerning the role and underlying mechanism of fasting in physiology and pathology are summarized, the therapeutic potential of fasting is highlighted, and the combination of pharmacological intervention and fasting is discussed as a new treatment regimen for human diseases. |
format | Online Article Text |
id | pubmed-10037992 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100379922023-03-25 Fasting: From Physiology to Pathology Tang, Dongmei Tang, Qiuyan Huang, Wei Zhang, Yuwei Tian, Yan Fu, Xianghui Adv Sci (Weinh) Reviews Overnutrition is a risk factor for various human diseases, including neurodegenerative diseases, metabolic disorders, and cancers. Therefore, targeting overnutrition represents a simple but attractive strategy for the treatment of these increasing public health threats. Fasting as a dietary intervention for combating overnutrition has been extensively studied. Fasting has been practiced for millennia, but only recently have its roles in the molecular clock, gut microbiome, and tissue homeostasis and function emerged. Fasting can slow aging in most species and protect against various human diseases, including neurodegenerative diseases, metabolic disorders, and cancers. These centuried and unfading adventures and explorations suggest that fasting has the potential to delay aging and help prevent and treat diseases while minimizing side effects caused by chronic dietary interventions. In this review, recent animal and human studies concerning the role and underlying mechanism of fasting in physiology and pathology are summarized, the therapeutic potential of fasting is highlighted, and the combination of pharmacological intervention and fasting is discussed as a new treatment regimen for human diseases. John Wiley and Sons Inc. 2023-02-03 /pmc/articles/PMC10037992/ /pubmed/36737846 http://dx.doi.org/10.1002/advs.202204487 Text en © 2023 The Authors. Advanced Science published by Wiley‐VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Reviews Tang, Dongmei Tang, Qiuyan Huang, Wei Zhang, Yuwei Tian, Yan Fu, Xianghui Fasting: From Physiology to Pathology |
title | Fasting: From Physiology to Pathology |
title_full | Fasting: From Physiology to Pathology |
title_fullStr | Fasting: From Physiology to Pathology |
title_full_unstemmed | Fasting: From Physiology to Pathology |
title_short | Fasting: From Physiology to Pathology |
title_sort | fasting: from physiology to pathology |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10037992/ https://www.ncbi.nlm.nih.gov/pubmed/36737846 http://dx.doi.org/10.1002/advs.202204487 |
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