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Succinate metabolism and its regulation of host-microbe interactions

Succinate is a circulating metabolite, and the relationship between abnormal changes in the physiological concentration of succinate and inflammatory diseases caused by the overreaction of certain immune cells has become a research focus. Recent investigations have shown that succinate produced by t...

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Autores principales: Wei, Yi-han, Ma, Xi, Zhao, Jiang-Chao, Wang, Xiu-Qi, Gao, Chun-Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10038034/
https://www.ncbi.nlm.nih.gov/pubmed/36946592
http://dx.doi.org/10.1080/19490976.2023.2190300
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author Wei, Yi-han
Ma, Xi
Zhao, Jiang-Chao
Wang, Xiu-Qi
Gao, Chun-Qi
author_facet Wei, Yi-han
Ma, Xi
Zhao, Jiang-Chao
Wang, Xiu-Qi
Gao, Chun-Qi
author_sort Wei, Yi-han
collection PubMed
description Succinate is a circulating metabolite, and the relationship between abnormal changes in the physiological concentration of succinate and inflammatory diseases caused by the overreaction of certain immune cells has become a research focus. Recent investigations have shown that succinate produced by the gut microbiota has the potential to regulate host homeostasis and treat diseases such as inflammation. Gut microbes are important for maintaining intestinal homeostasis. Microbial metabolites serve as nutrients in energy metabolism, and act as signal molecules that stimulate host cell and organ function and affect the structural balance between symbiotic gut microorganisms. This review focuses on succinate as a metabolite of both host cells and gut microbes and its involvement in regulating the gut – immune tissue axis by activating intestinal mucosal cells, including macrophages, dendritic cells, and intestinal epithelial cells. We also examined its role as the mediator of microbiota – host crosstalk and its potential function in regulating intestinal microbiota homeostasis. This review explores feasible ways to moderate succinate levels and provides new insights into succinate as a potential target for microbial therapeutics for humans.
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spelling pubmed-100380342023-03-25 Succinate metabolism and its regulation of host-microbe interactions Wei, Yi-han Ma, Xi Zhao, Jiang-Chao Wang, Xiu-Qi Gao, Chun-Qi Gut Microbes Review Succinate is a circulating metabolite, and the relationship between abnormal changes in the physiological concentration of succinate and inflammatory diseases caused by the overreaction of certain immune cells has become a research focus. Recent investigations have shown that succinate produced by the gut microbiota has the potential to regulate host homeostasis and treat diseases such as inflammation. Gut microbes are important for maintaining intestinal homeostasis. Microbial metabolites serve as nutrients in energy metabolism, and act as signal molecules that stimulate host cell and organ function and affect the structural balance between symbiotic gut microorganisms. This review focuses on succinate as a metabolite of both host cells and gut microbes and its involvement in regulating the gut – immune tissue axis by activating intestinal mucosal cells, including macrophages, dendritic cells, and intestinal epithelial cells. We also examined its role as the mediator of microbiota – host crosstalk and its potential function in regulating intestinal microbiota homeostasis. This review explores feasible ways to moderate succinate levels and provides new insights into succinate as a potential target for microbial therapeutics for humans. Taylor & Francis 2023-03-22 /pmc/articles/PMC10038034/ /pubmed/36946592 http://dx.doi.org/10.1080/19490976.2023.2190300 Text en © 2023 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.
spellingShingle Review
Wei, Yi-han
Ma, Xi
Zhao, Jiang-Chao
Wang, Xiu-Qi
Gao, Chun-Qi
Succinate metabolism and its regulation of host-microbe interactions
title Succinate metabolism and its regulation of host-microbe interactions
title_full Succinate metabolism and its regulation of host-microbe interactions
title_fullStr Succinate metabolism and its regulation of host-microbe interactions
title_full_unstemmed Succinate metabolism and its regulation of host-microbe interactions
title_short Succinate metabolism and its regulation of host-microbe interactions
title_sort succinate metabolism and its regulation of host-microbe interactions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10038034/
https://www.ncbi.nlm.nih.gov/pubmed/36946592
http://dx.doi.org/10.1080/19490976.2023.2190300
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