Downregulation of Plasma Membrane Ca(2+) ATPase driven by tyrosine hydroxylase-Gal4 reduces Drosophila lifespan independently of effects in neurons

In Drosophila melanogaster, several Gal4 drivers are used to direct gene/RNAi expression to different dopaminergic neuronal clusters. We previously developed a fly model of Parkinson’s disease, in which dopaminergic neurons had elevated cytosolic Ca(2+) due to the expression of a Plasma Membrane Ca(...

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Detalles Bibliográficos
Autores principales: Erhardt, Brenda, Frenkel, Lia, Marcora, María Silvina, Farías, María Isabel, Ferrari, Carina Cintia, Pitossi, Fernando Juan, Leal, María Celeste
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10038040/
https://www.ncbi.nlm.nih.gov/pubmed/36949021
http://dx.doi.org/10.1080/19336934.2023.2192457

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