Synthesis, biological evaluation and theoretical studies of (E)-1-(4-sulfamoyl-phenylethyl)-3-arylidene-5-aryl-1H-pyrrol-2(3H)-ones as human carbonic anhydrase inhibitors

A series of 20 newly designed (E)-1-(4-sulphamoylphenylethyl)-3-arylidene-5-aryl-1H-pyrrol-2(3H)-ones was synthesised and assessed as carbonic anhydrase (CA, EC 4.2.1.1) inhibitors towards four human isoforms of pharmaceutical interest, that is, hCA I, II, IX and XII. The compounds displayed low to...

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Detalles Bibliográficos
Autores principales: Ramzan, Farhat, Nabi, Syed Ayaz, Lone, Mehak Saba, Bonardi, Alessandro, Hamid, Aabid, Bano, Sameena, Sharma, Kalicharan, Shafi, Syed, Samim, Mohammed, Javed, Kalim, Supran, Claudiu T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10038056/
https://www.ncbi.nlm.nih.gov/pubmed/36950918
http://dx.doi.org/10.1080/14756366.2023.2189126

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