Metabolic Reprogramming and Its Regulatory Mechanism in Sepsis-Mediated Inflammation

Sepsis is a systemic inflammatory disease caused by an infection that can lead to multiple organ failure. Sepsis alters energy metabolism, leading to metabolic reprogramming of immune cells, which consequently disrupts innate and adaptive immune responses, triggering hyperinflammation and immunosupp...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Wenzhang, Liu, Tianyi, Zheng, Yongjun, Xia, Zhaofan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10038208/
https://www.ncbi.nlm.nih.gov/pubmed/36968575
http://dx.doi.org/10.2147/JIR.S403778
_version_ 1784912031470583808
author Liu, Wenzhang
Liu, Tianyi
Zheng, Yongjun
Xia, Zhaofan
author_facet Liu, Wenzhang
Liu, Tianyi
Zheng, Yongjun
Xia, Zhaofan
author_sort Liu, Wenzhang
collection PubMed
description Sepsis is a systemic inflammatory disease caused by an infection that can lead to multiple organ failure. Sepsis alters energy metabolism, leading to metabolic reprogramming of immune cells, which consequently disrupts innate and adaptive immune responses, triggering hyperinflammation and immunosuppression. This review summarizes metabolic reprogramming and its regulatory mechanism in sepsis-induced hyperinflammation and immunosuppression, highlights the significance and intricacies of immune cell metabolic reprogramming, and emphasizes the pivotal role of mitochondria in metabolic regulation and treatment of sepsis. This review provides an up-to-date overview of the relevant literature to inform future research directions in understanding the regulation of sepsis immunometabolism. Metabolic reprogramming has great promise as a new target for sepsis treatment in the future.
format Online
Article
Text
id pubmed-10038208
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Dove
record_format MEDLINE/PubMed
spelling pubmed-100382082023-03-25 Metabolic Reprogramming and Its Regulatory Mechanism in Sepsis-Mediated Inflammation Liu, Wenzhang Liu, Tianyi Zheng, Yongjun Xia, Zhaofan J Inflamm Res Review Sepsis is a systemic inflammatory disease caused by an infection that can lead to multiple organ failure. Sepsis alters energy metabolism, leading to metabolic reprogramming of immune cells, which consequently disrupts innate and adaptive immune responses, triggering hyperinflammation and immunosuppression. This review summarizes metabolic reprogramming and its regulatory mechanism in sepsis-induced hyperinflammation and immunosuppression, highlights the significance and intricacies of immune cell metabolic reprogramming, and emphasizes the pivotal role of mitochondria in metabolic regulation and treatment of sepsis. This review provides an up-to-date overview of the relevant literature to inform future research directions in understanding the regulation of sepsis immunometabolism. Metabolic reprogramming has great promise as a new target for sepsis treatment in the future. Dove 2023-03-20 /pmc/articles/PMC10038208/ /pubmed/36968575 http://dx.doi.org/10.2147/JIR.S403778 Text en © 2023 Liu et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Liu, Wenzhang
Liu, Tianyi
Zheng, Yongjun
Xia, Zhaofan
Metabolic Reprogramming and Its Regulatory Mechanism in Sepsis-Mediated Inflammation
title Metabolic Reprogramming and Its Regulatory Mechanism in Sepsis-Mediated Inflammation
title_full Metabolic Reprogramming and Its Regulatory Mechanism in Sepsis-Mediated Inflammation
title_fullStr Metabolic Reprogramming and Its Regulatory Mechanism in Sepsis-Mediated Inflammation
title_full_unstemmed Metabolic Reprogramming and Its Regulatory Mechanism in Sepsis-Mediated Inflammation
title_short Metabolic Reprogramming and Its Regulatory Mechanism in Sepsis-Mediated Inflammation
title_sort metabolic reprogramming and its regulatory mechanism in sepsis-mediated inflammation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10038208/
https://www.ncbi.nlm.nih.gov/pubmed/36968575
http://dx.doi.org/10.2147/JIR.S403778
work_keys_str_mv AT liuwenzhang metabolicreprogramminganditsregulatorymechanisminsepsismediatedinflammation
AT liutianyi metabolicreprogramminganditsregulatorymechanisminsepsismediatedinflammation
AT zhengyongjun metabolicreprogramminganditsregulatorymechanisminsepsismediatedinflammation
AT xiazhaofan metabolicreprogramminganditsregulatorymechanisminsepsismediatedinflammation

Ejemplares similares